RPS6KB2
Ribosomal Protein S6 Kinase B2
Gene Information Card
| Symbol | RPS6KB2 |
|---|---|
| Full Name | Ribosomal Protein S6 Kinase B2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 6199 ncbi.nlm.nih.gov/gene/6199 |
| Ensembl ID | ENSG00000175634 |
| UniProt ID | Q9UBS0 |
| OMIM ID | 608938 |
| HGNC ID | 10436 |
| Aliases | S6K-beta-2, p70S6Kb, S6K2, STK14B |
Description
RPS6KB2 encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. This kinase is activated downstream of the mTOR and PI3K signaling pathways and phosphorylates the S6 ribosomal protein, promoting translation and cell growth. It is involved in cell proliferation, survival, and metabolism. Overexpression and mutations have been implicated in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Amplification and overexpression of RPS6KB2 lead to increased mTOR signaling and cell proliferation | COSMIC; PMID: 15607980 |
| Prostate cancer | Upregulation of RPS6KB2 correlates with poor prognosis and androgen receptor signaling | PMID: 22926524 |
| Colorectal cancer | RPS6KB2 mutations and copy number gains contribute to tumor growth via S6 phosphorylation | COSMIC; PMID: 23535649 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Medium |
| Colon | 10.1 | Medium |
| Lung | 7.9 | Low |
| Prostate | 9.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.2 | High expression |
| PC3 (prostate cancer) | 11.8 | Medium expression |
| HCT116 (colorectal cancer) | 13.5 | High expression |
| A549 (lung cancer) | 8.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1250A>G (p.Asn417Ser) | Missense | <1% | Unknown functional effect |
| c.172C>T (p.Arg58Trp) | Missense | <0.5% | Potential loss of function |
| Amplification | Copy number gain | ~5% in breast cancer | Increased kinase activity |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Arg58Trp) may reduce kinase activity, but no clear LOF phenotype established.
Gain of Function (GOF)
Amplification and overexpression in cancers lead to increased S6 phosphorylation and enhanced mTOR signaling.
Dominant Negative (DN)
No dominant negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• mTOR signaling pathway (KEGG: hsa04150)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Insulin signaling pathway (KEGG: hsa04910)
Protein Summary
RPS6KB2 (S6K-beta-2) is a 495-amino acid serine/threonine kinase with an N-terminal kinase domain and a C-terminal regulatory domain. It is activated by phosphorylation at Thr228 and Ser423 via mTORC1 and PDK1. The protein phosphorylates ribosomal protein S6, eIF4B, and other substrates to promote cap-dependent translation and cell growth. It is widely expressed and frequently dysregulated in cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| RPS6KB2 Knockout HEK293 Cell Line | EDJ-KQ125 | Human | 6199 | Details Get a Quote |
| RPS6KB2 Knockout A-549 Cell Line | EDJ-KQ18630 | Human | 6199 | Details Get a Quote |
| RPS6KB2 Knockout HCT 116 Cell Line | EDJ-KQ18632 | Human | 6199 | Details Get a Quote |
| RPS6KB2 Knockout HeLa Cell Line | EDJ-KQ18633 | Human | 6199 | Details Get a Quote |
