Overview
Drug Metabolism (CYP450)
Study cytochrome P450 enzyme expression, activity and regulation, drug–drug interactions and pharmacogenomics using CRISPR-engineered cell models.
What is Drug Metabolism (CYP450) ?
Cytochrome P450 enzymes are a superfamily of heme-containing monooxygenases responsible for the oxidative metabolism of the majority of drugs, xenobiotics and endogenous compounds. CYP450 activity determines drug clearance, half-life and toxicity. Polymorphisms and induction/inhibition by co-administered drugs are major sources of adverse drug reactions.
Key Research Applications
CYP isoform-specific metabolism assays
Drug–drug interaction screening
Pharmacogenetic variant modeling
Metabolic stability profiling
Toxicity and reactive metabolite assessment
Products
Featured/Popular Targets
ALL
CYP51A1
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CYP51A1 Knockout HEK293 Cell Line | EDJ-KQ13085 | Human | 1595 | Details Get a Quote |
| CYP51A1 Knockout A-549 Cell Line | EDJ-KQ41138 | Human | 1595 | Details Get a Quote |
| CYP51A1 Knockout HCT 116 Cell Line | EDJ-KQ26294 | Human | 1595 | Details Get a Quote |
| CYP51A1 Knockout HeLa Cell Line | EDJ-KQ42367 | Human | 1595 | Details Get a Quote |
| CYP51A1 Knockout Hep-G2 Cell Line | EDJ-KZ176 | Human | 1595 | Details Get a Quote |
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