Overview
Heart Failure & Remodeling
Study cardiac remodeling, hypertrophic signaling, fibrosis and heart failure progression using CRISPR-engineered cardiomyocyte and animal models.
What is Heart Failure & Remodeling ?
Heart failure is a clinical syndrome in which the heart cannot pump sufficient blood to meet the body's needs, often preceded by adverse cardiac remodeling involving cardiomyocyte hypertrophy, apoptosis and interstitial fibrosis. Molecular pathways such as calcineurin-NFAT, β-adrenergic and MAPK signaling drive remodeling, representing therapeutic targets for heart failure.
Key Research Applications
Cardiomyocyte hypertrophy assays
Fibroblast-to-myofibroblast transition studies
Fibrosis gene target validation
β-AR signaling pathway analysis
Heart failure biomarker discovery
Products
Featured/Popular Targets
ALL
SLC8A1
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SLC8A1 Knockout HEK293 Cell Line | EDJ-KQ849 | Human | 6546 | Details Get a Quote |
| SLC8A1 Knockout HeLa Cell Line | EDJ-KQ54500 | Human | 6546 | Details Get a Quote |
| SLC8A1 Knockout A-549 Cell Line | EDJ-KQ62986 | Human | 6546 | Details Get a Quote |
| SLC8A1 Knockout HCT 116 Cell Line | EDJ-KQ71457 | Human | 6546 | Details Get a Quote |
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