Overview
Nuclear Transport
Study nucleocytoplasmic transport, importin/exportin pathways, nuclear pore complex function and their roles in signaling and disease using CRISPR-engineered cell models.
What is Nuclear Transport ?
Nuclear transport is the selective, receptor-mediated trafficking of macromolecules between the nucleus and cytoplasm through nuclear pore complexes (NPCs). Importins and exportins recognize cargo via nuclear localization (NLS) or export (NES) signals and the Ran GTPase gradient. NPC defects and transport misregulation are linked to cancer, neurodegeneration (ALS) and viral pathogenesis.
Key Research Applications
Nuclear import/export reporter assays (NLS/NES-GFP)
Importin/exportin knockout cargo localization screens
Nuclear pore complex component depletion studies
Ran GTPase gradient manipulation and effects
Viral protein nuclear trafficking analysis
Products
Featured/Popular Targets
ALL
XPO1
XPO5
KPNA2
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| KPNA2 Knockout HEK293 Cell Line | EDC07572 | Human | 3838 | Details Get a Quote |
| KPNA2 Knockout A-549 Cell Line | EDJ-KQ23470 | Human | 3838 | Details Get a Quote |
| KPNA2 Knockout HCT 116 Cell Line | EDJ-KQ24863 | Human | 3838 | Details Get a Quote |
| KPNA2 Knockout HeLa Cell Line | EDJ-KQ24864 | Human | 3838 | Details Get a Quote |
| lentiCRISPR v3-XPO5-sgRNA1-puro | EDV2819 | 57510 | Details Get a Quote | |
| lentiCRISPR v3-XPO5-sgRNA2-puro | EDV2820 | 57510 | Details Get a Quote | |
| XPO5 Knockout RPE1 hTERT p53-/- Cell Line | EDC08267 | Human | 57510 | Details Get a Quote |
| XPO1 Knockout HEK293 Cell Line | EDC07601 | Human | 7514 | Details Get a Quote |
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