Overview
Hypoxia Response
Study HIF transcription factor stabilization, hypoxic gene regulation and cellular adaptation to low oxygen using CRISPR-engineered cell models.
What is Hypoxia Response ?
The hypoxia response is mediated primarily by hypoxia-inducible factors (HIF-1α, HIF-2α), which are stabilized under low oxygen and activate genes controlling angiogenesis, metabolism and survival. Hypoxia is a hallmark of solid tumors and drives therapy resistance and metastasis. Prolyl hydroxylases (PHDs) and VHL are key regulators.
Key Research Applications
HIF-1α/HIF-2α stabilization kinetics (CoCl2
1% O2)
Hypoxia response element (HRE) luciferase reporters
Tumor hypoxia spheroid/organoid modeling
PHD/VHL gene knockout and HIF pathway analysis
Hypoxia-activated prodrug screening
Products
Featured/Popular Targets
ALL
HIF1A
VEGFA
VEGFB
VEGFC
VEGFD
BNIP3
BNIP3L
SLC2A1
PDGFB
Product name Cat.No. Species Gene ID
VEGFC Knockout HEK293 Cell Line EDJ-KQ251 Human 7424 Details Get a Quote
VEGFD Knockout HEK293 Cell Line EDJ-KQ763 Human 2277 Details Get a Quote
BNIP3 Knockout HEK293 Cell Line EDJ-KQ1023 Human 664 Details Get a Quote
PDGFB Knockout HEK293 Cell Line EDJ-KQ1198 Human 5155 Details Get a Quote
HIF1A Knockout HEK293 Cell Line EDJ-KQ1494 Human 3091 Details Get a Quote
SLC2A1 Knockout HEK293 Cell Line EDC08016 Human 6513 Details Get a Quote
BNIP3L Knockout HEK293 Cell Line EDJ-KQ12552 Human 665 Details Get a Quote
VEGFA Knockout HEK293 Cell Line EDJ-KQ17674 Human 7422 Details Get a Quote
VEGFB Knockout HEK293 Cell Line EDJ-KQ17773 Human 7423 Details Get a Quote
BNIP3L Knockout HeLa Cell Line EDJ-KQ18103 Human 665 Details Get a Quote
PDGFB Knockout HeLa Cell Line EDJ-KQ19148 Human 5155 Details Get a Quote
BNIP3 Knockout A-549 Cell Line EDJ-KQ20110 Human 664 Details Get a Quote
BNIP3 Knockout HCT 116 Cell Line EDJ-KQ20111 Human 664 Details Get a Quote
HIF1A Knockout A-549 Cell Line EDJ-KQ21098 Human 3091 Details Get a Quote
HIF1A Knockout HCT 116 Cell Line EDJ-KQ21099 Human 3091 Details Get a Quote
Displaying Records 1 To 15 Of 44 Records
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