Overview
Neurodegenerative Diseases
Study protein aggregation, mitochondrial dysfunction, neuroinflammation and disease-associated pathways in neurodegeneration using CRISPR-engineered cell and organoid models.
What is Neurodegenerative Diseases ?
Neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS and Huntington's, involve progressive loss of neurons. Shared mechanisms include misfolded protein aggregation, impaired proteostasis, mitochondrial failure and neuroinflammation. CRISPR models with disease-relevant mutations enable dissection of pathogenic cascades and drug target discovery.
Key Research Applications
Amyloid-beta/tau pathology modeling
α-synuclein aggregation assays
TDP-43 mislocalization studies
Neuroprotection drug screening
Products
Featured/Popular Targets
ALL
APP
SNCA
SNCB
HTT
LRRK2
PARK7
PINK1
PRKN
GBA1
ATXN3
FUS
SQSTM1
OPTN
TBK1
Product name Cat.No. Species Gene ID
PARK7 Knockout HT22 Cell Line EDJ-KQ72 Mouse 57320 Details Get a Quote
SQSTM1 Knockout HEK293 Cell Line EDC08337 Human 8878 Details Get a Quote
OPTN Knockout HEK293T Cell Line EDJ-KQ197 Human 10133 Details Get a Quote
SNCA Knockout HEK293 Cell Line EDJ-KQ954 Human 6622 Details Get a Quote
PARK7 Knockout HEK293 Cell Line EDJ-KQ969 Human 11315 Details Get a Quote
FUS Knockout HEK293 Cell Line EDC07631 Human 2521 Details Get a Quote
OPTN Knockout HEK293 Cell Line EDJ-KQ2061 Human 10133 Details Get a Quote
PRKN Knockout HEK293 Cell Line EDJ-KQ3360 Human 5071 Details Get a Quote
PINK1 Knockout HEK293 Cell Line EDJ-KQ3426 Human 65018 Details Get a Quote
APP Knockout HEK293 Cell Line EDC09598 Human 351 Details Get a Quote
HTT Knockout HEK293 Cell Line EDJ-KQ4863 Human 3064 Details Get a Quote
ATXN3 Knockout HEK293 Cell Line EDJ-KQ5214 Human 4287 Details Get a Quote
LRRK2 Knockout HEK293 Cell Line EDJ-KQ7015 Human 120892 Details Get a Quote
GBA1 Knockout HEK293 Cell Line EDC90036 Human 2629 Details Get a Quote
TBK1 Knockout HEK293 Cell Line EDJ-KQ17906 Human 29110 Details Get a Quote
Displaying Records 1 To 15 Of 74 Records
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