Overview
Regulatory T Cell Biology
Study Treg differentiation, suppressive function, FOXP3 regulation and Treg roles in autoimmunity and cancer using CRISPR-engineered T cell models.
What is Regulatory T Cell Biology ?
Regulatory T cells (Tregs) are a CD4+ T cell subset expressing FOXP3 that suppresses immune responses to maintain self-tolerance and prevent autoimmunity. In tumors, Tregs can suppress anti-tumor immunity, making them a target for immunotherapy. CRISPR-based manipulation of Treg function has therapeutic potential for autoimmune disease and cancer.
Key Research Applications
In vitro Treg suppression assays
Treg stability and plasticity analysis
Tumor-infiltrating Treg depletion studies
Treg-specific gene function mapping
Products
Featured/Popular Targets
ALL
FOXP3
CTLA4
TGFB1
IL10
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CTLA4 Knockout HEK293 Cell Line | EDC07546 | Human | 1493 | Details Get a Quote |
| TGFB1 Knockout HEK293 Cell Line | EDJ-KQ17770 | Human | 7040 | Details Get a Quote |
| IL10 Knockout HEK293 Cell Line | EDJ-KQ50389 | Human | 3586 | Details Get a Quote |
| FOXP3 Knockout HEK293 Cell Line | EDJ-KQ51265 | Human | 50943 | Details Get a Quote |
| CTLA4 Knockout HeLa Cell Line | EDJ-KQ53023 | Human | 1493 | Details Get a Quote |
| IL10 Knockout HeLa Cell Line | EDJ-KQ53644 | Human | 3586 | Details Get a Quote |
| TGFB1 Knockout HeLa Cell Line | EDJ-KQ54648 | Human | 7040 | Details Get a Quote |
| FOXP3 Knockout HeLa Cell Line | EDJ-KQ56203 | Human | 50943 | Details Get a Quote |
| CTLA4 Knockout A-549 Cell Line | EDJ-KQ61487 | Human | 1493 | Details Get a Quote |
| IL10 Knockout A-549 Cell Line | EDJ-KQ62119 | Human | 3586 | Details Get a Quote |
| TGFB1 Knockout A-549 Cell Line | EDJ-KQ63128 | Human | 7040 | Details Get a Quote |
| FOXP3 Knockout A-549 Cell Line | EDJ-KQ64693 | Human | 50943 | Details Get a Quote |
| CTLA4 Knockout HCT 116 Cell Line | EDJ-KQ69982 | Human | 1493 | Details Get a Quote |
| IL10 Knockout HCT 116 Cell Line | EDJ-KQ70608 | Human | 3586 | Details Get a Quote |
| TGFB1 Knockout HCT 116 Cell Line | EDJ-KQ71601 | Human | 7040 | Details Get a Quote |
Displaying Records 1 To 15 Of 21 Records
