Overview
Autoimmunity & Inflammation
Study immune tolerance breakdown, inflammatory mediator production and autoimmune disease mechanisms using CRISPR-engineered cell models.
What is Autoimmunity & Inflammation ?
Autoimmunity arises when the immune system attacks self-tissues due to loss of tolerance, leading to chronic inflammation and tissue damage. Key pathways involve autoreactive T/B cells, cytokine dysregulation and genetic susceptibility. Understanding these mechanisms aids in the development of therapies for rheumatoid arthritis, lupus, multiple sclerosis and other autoimmune diseases.
Key Research Applications
Autoantigen-specific T cell assays
Cytokine pathway analysis
Regulatory immune cell studies
Inflammasome activation profiling
Immune checkpoint modulation screening
Products
Featured/Popular Targets
ALL
IL1B
IL6
TNF
IFNG
CTLA4
NFKB2
RELA
STAT3
IRF5
IRF7
IRAK1
IRAK4
Product name Cat.No. Species Gene ID
IFNg Overexpression HEK293 Stable Cell Line EDJ-GQ88 Human 3458 Details Get a Quote
IL1B Knockout HEK293 Cell Line EDJ-KQ140 Human 3553 Details Get a Quote
IL6 Knockout HEK293 Cell Line EDJ-KQ498 Human 3569 Details Get a Quote
IRAK4 Knockout HEK293 Cell Line EDJ-KQ569 Human 51135 Details Get a Quote
NFKB2 Knockout HEK293 Cell Line EDJ-KQ579 Human 4791 Details Get a Quote
RELA Knockout HEK293 Cell Line EDJ-KQ588 Human 5970 Details Get a Quote
STAT3 Knockout HEK293 Cell Line EDJ-KQ903 Human 6774 Details Get a Quote
IRF7 Knockout HEK293 Cell Line EDJ-KQ993 Human 3665 Details Get a Quote
IFNG Knockout HEK293 Cell Line EDJ-KQ1492 Human 3458 Details Get a Quote
IRF5 Knockout HEK293 Cell Line EDJ-KQ3840 Human 3663 Details Get a Quote
IRAK1 Knockout HEK293 Cell Line EDJ-KQ3940 Human 3654 Details Get a Quote
TNF Knockout HEK293 Cell Line EDJ-KQ17672 Human 7124 Details Get a Quote
CTLA4 Knockout HEK293 Cell Line EDC07546 Human 1493 Details Get a Quote
STAT3 Knockout HeLa Cell Line EDJ-KQ18072 Human 6774 Details Get a Quote
IL1B Knockout HeLa Cell Line EDJ-KQ18960 Human 3553 Details Get a Quote
Displaying Records 1 To 15 Of 53 Records
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