Overview
Drug Metabolism (Phase I)
Study Phase I drug-metabolizing enzymes (oxidation, reduction, hydrolysis), substrate specificity and metabolite formation using CRISPR-engineered cell models.
What is Drug Metabolism (Phase I) ?
Phase I metabolism introduces or unmasks functional groups on drugs through oxidation, reduction or hydrolysis, primarily catalyzed by CYP450 enzymes but also by flavin-containing monooxygenases and esterases. These reactions often generate metabolites for Phase II conjugation and can produce pharmacologically active or toxic intermediates, making Phase I metabolism central to drug safety and efficacy.
Key Research Applications
Phase I enzyme panel screening
Metabolite identification and profiling
Enzyme induction/inhibition assays
Prodrug activation studies
Inter-individual variability modeling
Products
Featured/Popular Targets
ALL
CYP51A1
ADH5
ALDH1A1
NQO2
MAOA
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MAOA Knockout HEK293T Cell Line | EDJ-KQ219 | Human | 4128 | Details Get a Quote |
| ALDH1A1 Knockout HEK293 Cell Line | EDJ-KQ2024 | Human | 216 | Details Get a Quote |
| NQO2 Knockout HEK293 Cell Line | EDJ-KQ2186 | Human | 4835 | Details Get a Quote |
| MAOA Knockout HEK293 Cell Line | EDJ-KQ2873 | Human | 4128 | Details Get a Quote |
| ADH5 Knockout HEK293 Cell Line | EDJ-KQ4010 | Human | 128 | Details Get a Quote |
| CYP51A1 Knockout HEK293 Cell Line | EDJ-KQ13085 | Human | 1595 | Details Get a Quote |
| ALDH1A1 Knockout A-549 Cell Line | EDJ-KQ22054 | Human | 216 | Details Get a Quote |
| ALDH1A1 Knockout HCT 116 Cell Line | EDJ-KQ22055 | Human | 216 | Details Get a Quote |
| ADH5 Knockout A-549 Cell Line | EDJ-KQ24993 | Human | 128 | Details Get a Quote |
| CYP51A1 Knockout A-549 Cell Line | EDJ-KQ41138 | Human | 1595 | Details Get a Quote |
| NQO2 Knockout A-549 Cell Line | EDJ-KQ22407 | Human | 4835 | Details Get a Quote |
| NQO2 Knockout HCT 116 Cell Line | EDJ-KQ22408 | Human | 4835 | Details Get a Quote |
| NQO2 Knockout HeLa Cell Line | EDJ-KQ22409 | Human | 4835 | Details Get a Quote |
| MAOA Knockout A-549 Cell Line | EDJ-KQ25292 | Human | 4128 | Details Get a Quote |
| MAOA Knockout HCT 116 Cell Line | EDJ-KQ25294 | Human | 4128 | Details Get a Quote |
Displaying Records 1 To 15 Of 23 Records
