Overview
Post-translational Modification
Study protein post-translational modifications (phosphorylation, ubiquitination, acetylation, glycosylation, SUMOylation) and their roles in signal transduction and disease using CRISPR-engineered cell models.
What is Post-translational Modification ?
Post-translational modifications (PTMs) are covalent processing events that alter protein function, localization, stability and interactions after translation. Key modifications include phosphorylation, ubiquitination, acetylation, methylation, glycosylation and SUMOylation. Aberrant PTM patterns drive cancer, neurodegeneration and metabolic diseases, and the enzymes that write, read and erase these marks are major drug targets.
Key Research Applications
Modification-specific antibody validation
Ubiquitin ligase/deubiquitinase substrate identification
Kinase/phosphatase signaling network mapping
Acetylation/methylation writer/eraser knockout
Global PTM proteomics sample preparation
Products
Featured/Popular Targets
ALL
BIRC2
BTRC
FBXW7
FBXW11
MDM2
RNF2
RNF41
RNF139
RNF185
RNF213
TRIM21
TRIM25
TRIM28
TRIM41
TRIM56
TRIM65
UBE3A
XIAP
STUB1
PRKN
ITCH
CUL4A
CUL4B
DZIP3
CYLD
OTUB1
OTUB2
OTUD1
OTUD3
OTUD4
OTUD5
OTUD6B
OTUD7B
STAMBP
STAMBPL1
USP1
USP2
USP4
USP6
USP7
USP10
USP11
USP13
USP14
USP15
USP16
USP18
USP19
USP20
USP21
USP22
USP24
USP25
USP27X
USP28
USP29
USP30
USP31
USP32
USP38
USP40
USP45
USP46
USP47
USP48
USP49
USP53
USP54
VCPIP1
JOSD1
SUMO1
SUMO3
SENP1
SENP2
SENP3
SENP5
SENP8
FUT1
FUT3
FUT8
ST3GAL5
ZDHHC21
POMK
EXT1
XYLT2
PPM1A
PPM1B
PPM1E
PPM1F
PPM1G
PPM1H
PPM1J
PPM1K
PPM1L
PPM1M
PPM1N
PPP1CA
PPP2CB
PPP3CA
PPP3CB
PPP3CC
PPP4R1
PPP4R2
PPP4R4
PPP5C
PPP6R1
PPP6R2
ILKAP
CTDNEP1
CTDSP1
CTDSP2
CTDSPL
Product name Cat.No. Species Gene ID
STUB1 Knockout MB49 Cell Line EDJ-KQ53 Mouse 56424 Details Get a Quote
FUT8 Knockout HEK293T Cell Line EDJ-KQ209 Human 2530 Details Get a Quote
BTRC Knockout HEK293 Cell Line EDJ-KQ281 Human 8945 Details Get a Quote
SENP2 Knockout HEK293 Cell Line EDJ-KQ331 Human 59343 Details Get a Quote
USP13 Knockout HEK293 Cell Line EDJ-KQ459 Human 8975 Details Get a Quote
BIRC2 Knockout HEK293 Cell Line EDJ-KQ543 Human 329 Details Get a Quote
CYLD Knockout HEK293 Cell Line EDJ-KQ560 Human 1540 Details Get a Quote
TRIM25 Knockout HEK293 Cell Line EDJ-KQ604 Human 7706 Details Get a Quote
PPM1A Knockout HEK293 Cell Line EDJ-KQ730 Human 5494 Details Get a Quote
PPM1B Knockout HEK293 Cell Line EDJ-KQ732 Human 5495 Details Get a Quote
PPP3CA Knockout HEK293 Cell Line EDJ-KQ733 Human 5530 Details Get a Quote
PPP3CB Knockout HEK293 Cell Line EDJ-KQ734 Human 5532 Details Get a Quote
PPP3CC Knockout HEK293 Cell Line EDJ-KQ735 Human 5533 Details Get a Quote
PPP5C Knockout HEK293 Cell Line EDJ-KQ737 Human 5536 Details Get a Quote
SENP1 Knockout HEK293 Cell Line EDJ-KQ957 Human 29843 Details Get a Quote
Displaying Records 1 To 15 Of 485 Records
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