Immunology
Immunology explores the activation, regulation, and effector mechanisms of both innate and adaptive immunity, involving a wide range of immune cells such as T cells, B cells, dendritic cells, and macrophages. Key signaling pathways, including TCR/BCR signaling, NF-κB signaling, JAK/STAT signaling, and immune checkpoint pathways, play critical roles in controlling inflammation, immune activation, and immune tolerance. Together, these pathways form complex regulatory networks that maintain balanced immune responses.
Disruptions in immune signaling can contribute to autoimmune diseases, chronic inflammation, infectious diseases, and tumor immune evasion. Understanding the molecular mechanisms of immune regulation is essential for identifying novel therapeutic targets and advancing immunotherapy development.
EDITGENE offers a collection of immunology knockout cell lines, covering pathways involved in positive regulation of interferon-alpha production, T-cell receptor signaling, B-cell receptor signaling, inflammatory signaling, and immune checkpoint regulation. These validated models support research in autoimmune diseases, inflammatory mechanisms, immune regulation, and tumor microenvironment studies.
We also provide ready-to-use and custom knockout cell lines to support a wide range of immunology and immunotherapy research applications, with additional pathway models continuously being added.
