Cardiovascular
Cardiovascular research focuses on the physiological functions and disease mechanisms of the heart and vascular system, including vascular development, endothelial function, cardiac contraction, and inflammatory responses. Key signaling pathways such as VEGF signaling, nitric oxide signaling, fluid shear stress response, and lipoprotein metabolism play essential roles in maintaining vascular homeostasis and cardiovascular function. Together, these pathways form a complex regulatory network that supports normal cardiovascular health.
Dysregulation of these pathways can contribute to diseases such as atherosclerosis, hypertension, heart failure, myocardial infarction, and abnormal angiogenesis. Understanding the molecular mechanisms underlying cardiovascular physiology and pathology is critical for identifying novel therapeutic targets and advancing cardiovascular drug development.
EDITGENE offers a collection of cardiovascular knockout cell lines, covering pathways involved in nitric oxide metabolism, nitric oxide biosynthesis, fluid shear stress response, vascular homeostasis, and vascular inflammation. These validated models support research in angiogenesis, vascular remodeling, cardiac repair, and cardiovascular disease mechanisms.
We also provide ready-to-use and custom knockout cell lines to support cardiovascular research and drug discovery, with additional pathway models continuously being added.
