Overview
Nucleotide Metabolism
Study purine and pyrimidine biosynthesis, salvage pathways and their roles in cell proliferation, cancer and immune function using CRISPR-engineered cell models.
What is Nucleotide Metabolism ?
Nucleotide metabolism provides the building blocks for DNA and RNA synthesis through de novo and salvage pathways. Rapidly dividing cancer and immune cells heavily rely on de novo nucleotide synthesis. Enzymes in this pathway (e.g., DHODH, IMPDH) are established therapeutic targets for cancer, autoimmune disease and antiviral therapy.
Key Research Applications
De novo vs salvage pathway utilization assays
Antimetabolite drug screening
Nucleotide pool size and imbalance studies
Cancer cell proliferation dependency profiling
Immunosuppressive agent mechanism analysis
Products
Featured/Popular Targets
ALL
HPRT1
IMPDH2
PNP
NUDT6
NUDT8
NUDT9
NUDT19
NUDT7
DUS1L
DUS2
TRDMT1
POLB
POLE4
POLH
POLI
POLK
POLL
POLM
POLN
POLQ
Product name Cat.No. Species Gene ID
POLM Knockout HEK293 Cell Line EDJ-KQ1924 Human 27434 Details Get a Quote
POLN Knockout HEK293 Cell Line EDJ-KQ1928 Human 353497 Details Get a Quote
PNP Knockout HEK293 Cell Line EDJ-KQ2248 Human 4860 Details Get a Quote
POLK Knockout HEK293 Cell Line EDJ-KQ3042 Human 51426 Details Get a Quote
POLH Knockout HEK293 Cell Line EDJ-KQ3612 Human 5429 Details Get a Quote
HPRT1 Knockout HEK293 Cell Line EDJ-KQ3913 Human 3251 Details Get a Quote
TRDMT1 Knockout HEK293 Cell Line EDJ-KQ4474 Human 1787 Details Get a Quote
POLB Knockout HEK293 Cell Line EDJ-KQ4739 Human 5423 Details Get a Quote
POLQ Knockout HEK293 Cell Line EDC90479 Human 10721 Details Get a Quote
NUDT6 Knockout HEK293 Cell Line EDJ-KQ7310 Human 11162 Details Get a Quote
POLI Knockout HEK293 Cell Line EDJ-KQ7331 Human 11201 Details Get a Quote
POLL Knockout HEK293 Cell Line EDJ-KQ8768 Human 27343 Details Get a Quote
NUDT7 Knockout HEK293 Cell Line EDJ-KQ10779 Human 283927 Details Get a Quote
NUDT8 Knockout HEK293 Cell Line EDJ-KQ11023 Human 254552 Details Get a Quote
NUDT9 Knockout HEK293 Cell Line EDJ-KQ11333 Human 53343 Details Get a Quote
Displaying Records 1 To 15 Of 85 Records
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