Overview
Pain & Sensory Biology
Study nociceptor signaling, pain transduction, peripheral sensitization and analgesic mechanisms using CRISPR-engineered sensory neuron models.
What is Pain & Sensory Biology ?
Pain is mediated by specialized primary sensory neurons (nociceptors) that detect noxious stimuli. Ion channels (e.g., TRPV1, NaV1.7) and GPCRs transduce and modulate pain signals. Persistent pain involves peripheral and central sensitization. Genetic validation of pain targets using CRISPR supports development of non-opioid analgesics.
Key Research Applications
DRG neuron culture and transfection
Calcium imaging pain receptor assays
NaV channel functional characterization
Analgesic target validation
Inflammatory mediator pain sensitization studies
Products
Featured/Popular Targets
ALL
ASIC1
P2RX4
P2RX7
GABBR1
DRD2
DRD3
DRD4
TRPV1
Product name Cat.No. Species Gene ID
TRPV1 Overexpression HEK293 Stable Cell Line EDC01713 Human 7442 Details Get a Quote
P2RX7 Knockout HEK293 Cell Line EDJ-KQ968 Human 5027 Details Get a Quote
DRD2 Knockout HEK293 Cell Line EDC90437 Human 1813 Details Get a Quote
P2RX4 Knockout HEK293 Cell Line EDJ-KQ1573 Human 5025 Details Get a Quote
GABBR1 Knockout HEK293 Cell Line EDJ-KQ1787 Human 2550 Details Get a Quote
DRD4 Knockout HEK293 Cell Line EDJ-KQ2237 Human 1815 Details Get a Quote
DRD3 Knockout HEK293 Cell Line EDJ-KQ2726 Human 1814 Details Get a Quote
ASIC1 Knockout HEK293 Cell Line EDJ-KQ3259 Human 41 Details Get a Quote
TRPV1 Knockout HEK293 Cell Line EDJ-KQ15949 Human 7442 Details Get a Quote
TRPV1 Knockout A-549 Cell Line EDJ-KQ46975 Human 7442 Details Get a Quote
TRPV1 Knockout HCT 116 Cell Line EDJ-KQ46976 Human 7442 Details Get a Quote
TRPV1 Knockout HeLa Cell Line EDJ-KQ46977 Human 7442 Details Get a Quote
P2RX4 Knockout A-549 Cell Line EDJ-KQ19900 Human 5025 Details Get a Quote
P2RX4 Knockout HCT 116 Cell Line EDJ-KQ21257 Human 5025 Details Get a Quote
P2RX4 Knockout HeLa Cell Line EDJ-KQ21258 Human 5025 Details Get a Quote
Displaying Records 1 To 15 Of 37 Records
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