Overview
p53 Signaling
Study p53 tumor suppressor function, regulation, DNA damage response and cancer-associated p53 mutations using CRISPR-engineered cell models.
What is p53 Signaling ?
p53 (TP53) is a critical tumor suppressor that responds to cellular stress by inducing cell cycle arrest, apoptosis or senescence. It is mutated in over half of human cancers. MDM2-mediated degradation and post-translational modifications tightly regulate p53 activity. CRISPR enables modeling of specific p53 mutations and interrogation of gain-of-function effects.
Key Research Applications
p53 transcriptional activity reporter assays
DNA damage-induced cell cycle arrest studies
p53 knockout/mutant isogenic cell lines
MDM2 inhibitor screening
Gain-of-function mutant p53 characterization
Products
Featured/Popular Targets
ALL
TP53
TP53BP2
MDM2
CDKN1B
ATM
CHEK2
CASP3
CASP8
CASP9
BCL2L2
USP7
Product name Cat.No. Species Gene ID
TP53 Knockout HCT 116 Cell Line EDC07854 Human 7157 Details Get a Quote
CASP9 Knockout HEK293 Cell Line EDJ-KQ183 Human 842 Details Get a Quote
ATM Knockout HEK293T Cell Line EDJ-KQ211 Human 472 Details Get a Quote
CASP3 Knockout HEK293 Cell Line EDJ-KQ632 Human 836 Details Get a Quote
CDKN1B Knockout HEK293 Cell Line EDJ-KQ766 Human 1027 Details Get a Quote
TP53BP2 Knockout HEK293 Cell Line EDJ-KQ1381 Human 7159 Details Get a Quote
CASP8 Knockout HEK293 Cell Line EDJ-KQ1474 Human 841 Details Get a Quote
CHEK2 Knockout HEK293 Cell Line EDJ-KQ7330 Human 11200 Details Get a Quote
ATM Knockout HEK293 Cell Line EDJ-KQ17856 Human 472 Details Get a Quote
TP53 Knockout HEK293 Cell Line EDJ-KQ17910 Human 7157 Details Get a Quote
TP53 Knockout hTERT-RPE1 Cell Line EDC00205 Human 7157 Details Get a Quote
CASP3 Knockout HCT 116 Cell Line EDJ-KQ18053 Human 836 Details Get a Quote
TP53 Knockout HeLa Cell Line EDJ-KQ18086 Human 7157 Details Get a Quote
ATM Knockout A-549 Cell Line EDJ-KQ18114 Human 472 Details Get a Quote
TP53 Knockout A-549 Cell Line EDJ-KQ18198 Human 7157 Details Get a Quote
Displaying Records 1 To 15 Of 86 Records
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