Overview
T Cell Activation & Signaling
Study T cell receptor (TCR) signaling, co-stimulation, immune synapse formation and T cell effector function using CRISPR-engineered T cell models.
What is T Cell Activation & Signaling ?
T cell activation requires TCR recognition of peptide-MHC and co-stimulatory signals (CD28, etc.), triggering kinase cascades (LCK, ZAP70, LAT) and calcium flux. These events drive clonal expansion and differentiation into effector/memory cells. CRISPR-based engineering of TCR signaling underlies CAR-T and TCR-T cell therapy design.
Key Research Applications
NFAT/AP-1/NF-κB reporter assays
Calcium flux measurement
Immune synapse imaging
CAR-T cell potency optimization
Exhaustion and checkpoint pathway studies
Products
Featured/Popular Targets
ALL
CD3D
CD3E
CD8A
CD2
ITK
PLCG1
PLCG2
JAK2
STAT3
STAT1
NFATC3
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STAT1 Knockout HEK293 Cell Line | EDJ-KQ188 | Human | 6772 | Details Get a Quote |
| PLCG1 Knockout HEK293 Cell Line | EDJ-KQ582 | Human | 5335 | Details Get a Quote |
| PLCG2 Knockout HEK293 Cell Line | EDJ-KQ583 | Human | 5336 | Details Get a Quote |
| NFATC3 Knockout HEK293 Cell Line | EDJ-KQ714 | Human | 4775 | Details Get a Quote |
| STAT3 Knockout HEK293 Cell Line | EDJ-KQ903 | Human | 6774 | Details Get a Quote |
| CD8A Knockout HEK293 Cell Line | EDJ-KQ2015 | Human | 925 | Details Get a Quote |
| CD3E Knockout HEK293 Cell Line | EDJ-KQ3486 | Human | 916 | Details Get a Quote |
| CD3D Knockout HEK293 Cell Line | EDJ-KQ3526 | Human | 915 | Details Get a Quote |
| ITK Knockout HEK293 Cell Line | EDJ-KQ3755 | Human | 3702 | Details Get a Quote |
| CD2 Knockout HEK293 Cell Line | EDJ-KQ4209 | Human | 914 | Details Get a Quote |
| JAK2 Knockout HEK293 Cell Line | EDJ-KQ17828 | Human | 3717 | Details Get a Quote |
| PLCG1 Knockout HeLa Cell Line | EDJ-KQ18033 | Human | 5335 | Details Get a Quote |
| STAT3 Knockout HeLa Cell Line | EDJ-KQ18072 | Human | 6774 | Details Get a Quote |
| PLCG1 Knockout A-549 Cell Line | EDJ-KQ19000 | Human | 5335 | Details Get a Quote |
| PLCG1 Knockout HCT 116 Cell Line | EDJ-KQ19001 | Human | 5335 | Details Get a Quote |
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