Overview
Hippo Signaling
Study Hippo pathway kinases, YAP/TAZ transcriptional co-activators, organ size control and cancer mechanisms using CRISPR-engineered cell models.
What is Hippo Signaling ?
The Hippo signaling pathway is a conserved kinase cascade that regulates organ size by inhibiting cell proliferation and promoting apoptosis. Its core consists of MST and LATS kinases that phosphorylate and inhibit the transcriptional co-activators YAP and TAZ. Dysregulated Hippo-YAP/TAZ signaling drives tumorigenesis and is a promising target for cancer and regenerative medicine.
Key Research Applications
YAP/TAZ nuclear translocation assays
LATS1/2 knockout proliferation studies
TEAD reporter screening
Hippo pathway interactome profiling
Products
Featured/Popular Targets
ALL
LATS1
LATS2
STK3
TEAD1
TEAD2
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| STK3 Knockout HEK293 Cell Line | EDJ-KQ756 | Human | 6788 | Details Get a Quote |
| LATS2 Knockout HEK293 Cell Line | EDJ-KQ1084 | Human | 26524 | Details Get a Quote |
| LATS1 Knockout HEK293 Cell Line | EDJ-KQ1375 | Human | 9113 | Details Get a Quote |
| TEAD1 Knockout HEK293 Cell Line | EDJ-KQ1395 | Human | 7003 | Details Get a Quote |
| TEAD2 Knockout HEK293 Cell Line | EDJ-KQ1398 | Human | 8463 | Details Get a Quote |
| TEAD1 Knockout A-549 Cell Line | EDJ-KQ20920 | Human | 7003 | Details Get a Quote |
| TEAD1 Knockout HCT 116 Cell Line | EDJ-KQ20921 | Human | 7003 | Details Get a Quote |
| TEAD1 Knockout HeLa Cell Line | EDJ-KQ20922 | Human | 7003 | Details Get a Quote |
| TEAD2 Knockout A-549 Cell Line | EDC08382 | Human | 8463 | Details Get a Quote |
| TEAD2 Knockout HCT 116 Cell Line | EDJ-KQ20926 | Human | 8463 | Details Get a Quote |
| TEAD2 Knockout HeLa Cell Line | EDJ-KQ20927 | Human | 8463 | Details Get a Quote |
| STK3 Knockout A-549 Cell Line | EDJ-KQ19420 | Human | 6788 | Details Get a Quote |
| STK3 Knockout HCT 116 Cell Line | EDJ-KQ19421 | Human | 6788 | Details Get a Quote |
| STK3 Knockout HeLa Cell Line | EDJ-KQ19422 | Human | 6788 | Details Get a Quote |
| LATS1 Knockout A-549 Cell Line | EDJ-KQ19530 | Human | 9113 | Details Get a Quote |
Displaying Records 1 To 15 Of 24 Records
