Overview
Tumor Suppressors
Study tumor suppressor gene function, loss-of-heterozygosity mechanisms and tumor-suppressive pathways using CRISPR-engineered cell models.
What is Tumor Suppressors ?
Tumor suppressor genes (e.g., TP53, RB1, PTEN, BRCA1) restrain cell growth and promote genome stability. Their inactivation by mutation, deletion or epigenetic silencing drives tumorigenesis. CRISPR enables systematic knockout and complementation studies to define tumor suppressor function and synthetic lethal relationships for therapy.
Key Research Applications
Tumor suppressor knockout panels
Development of Tumor Inhibitors and Therapeutic Targets
Loss-of-heterozygosity mechanism studies
Synthetic lethality screening
Tumor suppressor pathway reactivation strategies
Products
Featured/Popular Targets
ALL
TP53
PTEN
RB1
BRCA1
BRCA2
CDKN1B
SMAD4
WT1
TSC1
TSC2
LATS1
LATS2
ARID1A
ARID1B
Product name Cat.No. Species Gene ID
TP53 Knockout HCT 116 Cell Line EDC07854 Human 7157 Details Get a Quote
ARID1A Knockout SNK-6 Cell Line EDJ-KQ64 Human 8289 Details Get a Quote
SMAD4 Knockout HEK293 Cell Line EDJ-KQ401 Human 4089 Details Get a Quote
CDKN1B Knockout HEK293 Cell Line EDJ-KQ766 Human 1027 Details Get a Quote
LATS2 Knockout HEK293 Cell Line EDJ-KQ1084 Human 26524 Details Get a Quote
ARID1A Knockout HEK293 Cell Line EDJ-KQ1091 Human 8289 Details Get a Quote
LATS1 Knockout HEK293 Cell Line EDJ-KQ1375 Human 9113 Details Get a Quote
WT1 Knockout HEK293 Cell Line EDJ-KQ2401 Human 7490 Details Get a Quote
ARID1B Knockout HEK293 Cell Line EDJ-KQ2848 Human 57492 Details Get a Quote
RB1 Knockout HEK293 Cell Line EDC07586 Human 5925 Details Get a Quote
TP53 Knockout HEK293 Cell Line EDJ-KQ17910 Human 7157 Details Get a Quote
TSC1 Knockout HEK293 Cell Line EDJ-KQ17911 Human 7248 Details Get a Quote
TSC2 Knockout HEK293 Cell Line EDJ-KQ17912 Human 7249 Details Get a Quote
TP53 Knockout hTERT-RPE1 Cell Line EDC00205 Human 7157 Details Get a Quote
RB1 Knockout A-549 Cell Line EDJ-KQ18063 Human 5925 Details Get a Quote
Displaying Records 1 To 15 Of 139 Records
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