Overview
DNA Damage & Repair
Study DNA damage response, repair pathways, genomic stability and cancer-associated DNA repair mechanisms using CRISPR-engineered cell models.
What is DNA Damage & Repair ?
DNA damage and repair are essential cellular processes that maintain genomic integrity and prevent the accumulation of harmful mutations. Cells rely on complex DNA damage response (DDR) pathways, including homologous recombination and non-homologous end joining, to detect and repair DNA lesions. Defects in DNA repair mechanisms contribute to cancer development, therapy resistance, and have become important targets for precision oncology and PARP inhibitor research.
Key Research Applications
DNA repair pathway studies
PARP inhibitor development
Genomic instability research
DNA damage response screening
Synthetic lethality studies
Products
Featured/Popular Targets
ALL
APEX1
APTX
ATM
BLM
BRCA1
BRCA2
BRCC3
CHEK2
DCLRE1C
ERCC5
ERCC6
ERCC8
FANCC
FANCE
FANCG
FANCI
FANCM
HLTF
LIG4
MGMT
MSH2
MSH5
MSH6
NEIL1
NHEJ1
NTHL1
OGG1
PALB2
PMS1
PMS2
POLB
POLE4
POLH
POLI
POLK
POLL
POLM
POLN
POLQ
PRKDC
RAD23B
RECQL4
SETMAR
TDG
TDP1
TOP1MT
TREX1
TRDMT1
UNG
XPA
XRCC4
MSH3
MLH1
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ATM Knockout HEK293T Cell Line | EDJ-KQ211 | Human | 472 | Details Get a Quote |
| PMS1 Knockout HEK293 Cell Line | EDC90185 | Human | 5378 | Details Get a Quote |
| POLM Knockout HEK293 Cell Line | EDJ-KQ1924 | Human | 27434 | Details Get a Quote |
| POLN Knockout HEK293 Cell Line | EDJ-KQ1928 | Human | 353497 | Details Get a Quote |
| APEX1 Knockout HEK293 Cell Line | EDJ-KQ2313 | Human | 328 | Details Get a Quote |
| ERCC6 Knockout HEK293 Cell Line | EDJ-KQ2368 | Human | 2074 | Details Get a Quote |
| FANCC Knockout HEK293 Cell Line | EDJ-KQ2465 | Human | 2176 | Details Get a Quote |
| PMS2 Knockout HEK293 Cell Line | EDC07583 | Human | 5395 | Details Get a Quote |
| XRCC4 Knockout HEK293 Cell Line | EDJ-KQ2752 | Human | 7518 | Details Get a Quote |
| POLK Knockout HEK293 Cell Line | EDJ-KQ3042 | Human | 51426 | Details Get a Quote |
| MGMT Knockout HEK293 Cell Line | EDJ-KQ3115 | Human | 4255 | Details Get a Quote |
| FANCG Knockout HEK293 Cell Line | EDJ-KQ3404 | Human | 2189 | Details Get a Quote |
| POLH Knockout HEK293 Cell Line | EDJ-KQ3612 | Human | 5429 | Details Get a Quote |
| MSH5 Knockout HEK293 Cell Line | EDJ-KQ3649 | Human | 4439 | Details Get a Quote |
| ERCC8 Knockout HEK293 Cell Line | EDJ-KQ4282 | Human | 1161 | Details Get a Quote |
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