Overview
Oncogenes
Study oncogene activation, oncogenic signaling, cancer cell addiction and oncogene-targeted therapy mechanisms using CRISPR-engineered cell models.
What is Oncogenes ?
Oncogenes are genes with the potential to cause cancer when mutated or overexpressed. They typically encode growth factors, receptors, signal transducers or transcription factors (e.g., MYC, RAS, EGFR, HER2). Cancer cells often become 'addicted' to oncogene activity, creating therapeutic windows. CRISPR-based oncogene knockout validates their role in tumor maintenance.
Key Research Applications
Oncogene addiction and dependency assays
Mutant allele-specific knockout
Targeted therapy resistance modeling
Oncogenic signaling pathway mapping
Products
Featured/Popular Targets
ALL
AKT1
AKT2
AKT3
EGFR
ERBB2
ERBB3
MYC
MYCN
CCND1
CCNE1
CTNNB1
JUN
FOS
MDM2
PIK3CA
PIK3CB
PIK3CD
Product name Cat.No. Species Gene ID
CTNNB1 Knockout HCT 116 Cell Line EDJ-KQ22 Human 1499 Details Get a Quote
PIK3CA Knockout Hep-G2 Cell Line EDJ-KQ40 Human 5290 Details Get a Quote
JUN Knockout HEK293 Cell Line EDJ-KQ176 Human 3725 Details Get a Quote
JUN Knockout HEK293T Cell Line EDJ-KQ184 Human 3725 Details Get a Quote
CTNNB1 Knockout HEK293 Cell Line EDC07547 Human 1499 Details Get a Quote
CCND1 Knockout HEK293 Cell Line EDC07534 Human 595 Details Get a Quote
AKT1 Knockout HEK293 Cell Line EDJ-KQ446 Human 207 Details Get a Quote
AKT2 Knockout HEK293 Cell Line EDJ-KQ448 Human 208 Details Get a Quote
AKT3 Knockout HEK293 Cell Line EDJ-KQ449 Human 10000 Details Get a Quote
PIK3CA Knockout HEK293 Cell Line EDJ-KQ518 Human 5290 Details Get a Quote
PIK3CB Knockout HEK293 Cell Line EDJ-KQ519 Human 5291 Details Get a Quote
ERBB3 Knockout HEK293 Cell Line EDJ-KQ654 Human 2065 Details Get a Quote
FOS Knockout HEK293 Cell Line EDJ-KQ669 Human 2353 Details Get a Quote
MYCN Knockout HEK293 Cell Line EDJ-KQ3843 Human 4613 Details Get a Quote
CCNE1 Knockout HEK293 Cell Line EDC07535 Human 898 Details Get a Quote
Displaying Records 1 To 15 Of 133 Records
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