Overview
RAS Signaling
Study RAS GTPase biology, effector pathway engagement (RAF, PI3K, RAL), and RAS-driven cancer mechanisms using CRISPR-engineered cell models.
What is RAS Signaling ?
RAS proteins (KRAS, NRAS, HRAS) are small GTPases that act as molecular switches linking receptor tyrosine kinases to downstream signaling. Activating RAS mutations are among the most common oncogenic events in human cancer. Recent breakthroughs include FDA-approved KRAS G12C inhibitors, spurring intense research into RAS biology and inhibitor combinations.
Key Research Applications
GTP-bound RAS activation assays
KRAS allele-specific knockout/knockin
RAS-effector interaction disruption studies
G12C/D inhibitor sensitivity profiling
RAS-driven tumor dependency screening
Products
Featured/Popular Targets
ALL
RAF1
ARAF
MAP2K1
MAPK1
MAPK3
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ARAF Knockout HEK293 Cell Line | EDJ-KQ221 | Human | 369 | Details Get a Quote |
| MAPK1 Knockout HEK293 Cell Line | EDJ-KQ390 | Human | 5594 | Details Get a Quote |
| MAPK3 Knockout HEK293 Cell Line | EDJ-KQ391 | Human | 5595 | Details Get a Quote |
| MAP2K1 Knockout HEK293 Cell Line | EDJ-KQ17832 | Human | 5604 | Details Get a Quote |
| ARAF Knockout A-549 Cell Line | EDJ-KQ21180 | Human | 369 | Details Get a Quote |
| ARAF Knockout HCT 116 Cell Line | EDJ-KQ21181 | Human | 369 | Details Get a Quote |
| ARAF Knockout HeLa Cell Line | EDJ-KQ21182 | Human | 369 | Details Get a Quote |
| MAPK1 Knockout A-549 Cell Line | EDJ-KQ18602 | Human | 5594 | Details Get a Quote |
| MAPK1 Knockout HCT 116 Cell Line | EDJ-KQ18603 | Human | 5594 | Details Get a Quote |
| MAPK1 Knockout HeLa Cell Line | EDC90508 | Human | 5594 | Details Get a Quote |
| MAPK3 Knockout A-549 Cell Line | EDJ-KQ18605 | Human | 5595 | Details Get a Quote |
| MAPK3 Knockout HCT 116 Cell Line | EDJ-KQ18606 | Human | 5595 | Details Get a Quote |
| MAPK3 Knockout HeLa Cell Line | EDJ-KQ18607 | Human | 5595 | Details Get a Quote |
| MAP2K1 Knockout A-549 Cell Line | EDJ-KQ20479 | Human | 5604 | Details Get a Quote |
| MAP2K1 Knockout HCT 116 Cell Line | EDJ-KQ20480 | Human | 5604 | Details Get a Quote |
Displaying Records 1 To 15 Of 22 Records
