Overview
Drug Targets
Study therapeutic target identification, validation, selectivity profiling and mechanism of action using CRISPR-engineered cell models.
What is Drug Targets ?
Drug targets are specific biomolecules (typically proteins) that interact with therapeutic agents to produce a pharmacological effect. Validating a drug target requires demonstrating that its modulation alters disease-relevant phenotypes. CRISPR technologies enable precise target validation through knockout, knockin or point mutation modeling, supporting the development of more selective and effective drugs.
Key Research Applications
Target essentiality and dependency screening
On-target vs off-target selectivity profiling
Resistance-conferring mutation identification
Chemical-genetic interaction mapping
Patient-derived mutation functional validation
Products
Featured/Popular Targets
ALL
EGFR
ERBB2
ERBB3
JAK2
CDK2
CDK4
CDK6
HDAC3
HDAC4
HDAC5
HDAC6
HDAC7
HDAC8
HDAC9
HDAC10
HDAC11
VEGFA
KDR
PDGFRB
IGF1R
INSR
Product name Cat.No. Species Gene ID
ERBB3 Knockout HEK293 Cell Line EDJ-KQ654 Human 2065 Details Get a Quote
IGF1R Knockout HEK293 Cell Line EDC90491 Human 3480 Details Get a Quote
INSR Knockout HEK293 Cell Line EDJ-KQ679 Human 3643 Details Get a Quote
HDAC4 Knockout HEK293 Cell Line EDJ-KQ1457 Human 9759 Details Get a Quote
HDAC5 Knockout HEK293 Cell Line EDJ-KQ1458 Human 10014 Details Get a Quote
CDK2 Knockout HEK293 Cell Line EDC07797 Human 1017 Details Get a Quote
HDAC6 Knockout HEK293 Cell Line EDJ-KQ2396 Human 10013 Details Get a Quote
HDAC9 Knockout HEK293 Cell Line EDJ-KQ3111 Human 9734 Details Get a Quote
HDAC7 Knockout HEK293 Cell Line EDJ-KQ3535 Human 51564 Details Get a Quote
HDAC10 Knockout HEK293 Cell Line EDJ-KQ9937 Human 83933 Details Get a Quote
HDAC11 Knockout HEK293 Cell Line EDJ-KQ13729 Human 79885 Details Get a Quote
ERBB2 Knockout HEK293 Cell Line EDC90180 Human 2064 Details Get a Quote
VEGFA Knockout HEK293 Cell Line EDJ-KQ17674 Human 7422 Details Get a Quote
KDR Knockout HEK293 Cell Line EDJ-KQ17675 Human 3791 Details Get a Quote
PDGFRB Knockout HEK293 Cell Line EDJ-KQ17677 Human 5159 Details Get a Quote
Displaying Records 1 To 15 Of 125 Records
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