Overview
Stem Cell Maintenance & Differentiation
Study pluripotency networks, self-renewal, asymmetric division and directed differentiation using CRISPR-engineered pluripotent and adult stem cell models.
What is Stem Cell Maintenance & Differentiation ?
Stem cell maintenance preserves the undifferentiated, self-renewing state through core transcription factors (OCT4, SOX2, NANOG) and niche signals. Differentiation requires dissolution of this network and activation of lineage-specific programs. Balancing these states is critical for development, tissue homeostasis, and is exploited in regenerative medicine and cancer.
Key Research Applications
Alkaline phosphatase and pluripotency marker staining
Self-renewal (clonogenic
sphere formation) assays
Directed differentiation (ectoderm/mesoderm/endoderm) protocols
CRISPR screening for pluripotency exit regulators
Disease-specific iPSC line generation and differentiation
Products
Featured/Popular Targets
ALL
CTNNB1
MYC
KLF2
KLF4
GATA3
FOXO3
TGFB1
BMP2
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CTNNB1 Knockout HCT 116 Cell Line | EDJ-KQ22 | Human | 1499 | Details Get a Quote |
| CTNNB1 Knockout HEK293 Cell Line | EDC07547 | Human | 1499 | Details Get a Quote |
| BMP2 Knockout HEK293 Cell Line | EDJ-KQ367 | Human | 650 | Details Get a Quote |
| FOXO3 Knockout HEK293 Cell Line | EDJ-KQ795 | Human | 2309 | Details Get a Quote |
| GATA3 Knockout HEK293 Cell Line | EDJ-KQ1017 | Human | 2625 | Details Get a Quote |
| KLF4 Knockout HEK293 Cell Line | EDJ-KQ2519 | Human | 9314 | Details Get a Quote |
| TGFB1 Knockout HEK293 Cell Line | EDJ-KQ17770 | Human | 7040 | Details Get a Quote |
| CTNNB1 Knockout A-549 Cell Line | EDJ-KQ17963 | Human | 1499 | Details Get a Quote |
| CTNNB1 Knockout HeLa Cell Line | EDJ-KQ18136 | Human | 1499 | Details Get a Quote |
| GATA3 Knockout A-549 Cell Line | EDJ-KQ20091 | Human | 2625 | Details Get a Quote |
| GATA3 Knockout HCT 116 Cell Line | EDJ-KQ20092 | Human | 2625 | Details Get a Quote |
| KLF4 Knockout A-549 Cell Line | EDJ-KQ23130 | Human | 9314 | Details Get a Quote |
| KLF4 Knockout HeLa Cell Line | EDJ-KQ23132 | Human | 9314 | Details Get a Quote |
| FOXO3 Knockout HCT 116 Cell Line | EDJ-KQ18283 | Human | 2309 | Details Get a Quote |
| BMP2 Knockout HeLa Cell Line | EDJ-KQ18558 | Human | 650 | Details Get a Quote |
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