Overview
MAPK Signaling
Study the RAS-RAF-MEK-ERK cascade and related MAPK pathways, their regulation and roles in cancer and targeted therapy using CRISPR-engineered cell models.
What is MAPK Signaling ?
The mitogen-activated protein kinase (MAPK) cascade transmits signals from cell surface receptors to the nucleus, regulating proliferation, differentiation and survival. Hyperactivation through mutations in RAS, BRAF or MEK drives many cancers. MAPK pathway inhibitors are approved therapies, but resistance is a major challenge.
Key Research Applications
ERK phosphorylation and activity assays
BRAF V600E inhibitor sensitivity screening
Drug-resistant colony formation assays
RASopathy variant functional testing
Products
Featured/Popular Targets
ALL
MAPK1
MAPK3
MAPK6
MAPK7
MAPK8
MAPK9
MAPK11
MAPK14
MAPK15
MAP2K1
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP2K7
MAP3K1
MAP3K2
MAP3K3
MAP3K4
MAP3K5
MAP3K6
MAP3K7
MAP3K8
MAP3K9
MAP3K10
MAP3K11
MAP3K12
MAP3K14
MAP3K20
MAP3K21
MAP4K3
MAP4K4
MAP4K5
ARAF
RAF1
JUN
FOS
Product name Cat.No. Species Gene ID
MAP4K4 Knockout HEK293 Cell Line EDJ-KQ100 Human 9448 Details Get a Quote
MAP3K7 Knockout HEK293 Cell Line EDJ-KQ142 Human 6885 Details Get a Quote
JUN Knockout HEK293 Cell Line EDJ-KQ176 Human 3725 Details Get a Quote
JUN Knockout HEK293T Cell Line EDJ-KQ184 Human 3725 Details Get a Quote
MAP4K3 Knockout HEK293 Cell Line EDJ-KQ190 Human 8491 Details Get a Quote
MAPK8 Knockout HEK293 Cell Line EDJ-KQ193 Human 5599 Details Get a Quote
ARAF Knockout HEK293 Cell Line EDJ-KQ221 Human 369 Details Get a Quote
MAPK1 Knockout HEK293 Cell Line EDJ-KQ390 Human 5594 Details Get a Quote
MAPK3 Knockout HEK293 Cell Line EDJ-KQ391 Human 5595 Details Get a Quote
MAP3K14 Knockout HEK293 Cell Line EDJ-KQ577 Human 9020 Details Get a Quote
FOS Knockout HEK293 Cell Line EDJ-KQ669 Human 2353 Details Get a Quote
MAP2K3 Knockout HEK293 Cell Line EDJ-KQ681 Human 5606 Details Get a Quote
MAP2K4 Knockout HEK293 Cell Line EDJ-KQ682 Human 6416 Details Get a Quote
MAP2K7 Knockout HEK293 Cell Line EDJ-KQ684 Human 5609 Details Get a Quote
MAP3K1 Knockout HEK293 Cell Line EDJ-KQ685 Human 4214 Details Get a Quote
Displaying Records 1 To 15 Of 164 Records
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