Overview
Lipoprotein Metabolism
Study lipoprotein assembly, secretion, remodeling and receptor-mediated clearance using CRISPR-engineered hepatic and vascular cell models.
What is Lipoprotein Metabolism ?
Lipoprotein metabolism involves the production of VLDL by the liver, its conversion to LDL in circulation, and HDL-mediated reverse cholesterol transport. Key regulators include apolipoproteins, lipoprotein receptors (LDLR) and enzymes (PCSK9, CETP). Disruptions promote atherosclerosis and cardiovascular disease, and key nodes are established therapeutic targets.
Key Research Applications
LDL receptor activity and expression assays
PCSK9 functional studies
ApoB secretion quantification
HDL biogenesis and efflux assays
Atherogenic lipoprotein profiling
Products
Featured/Popular Targets
ALL
APOA1
APOA2
APOB
APOE
LDLR
SCARB1
ABCA1
ABCG1
LPL
Product name Cat.No. Species Gene ID
APOE Knockout HEK293 Cell Line EDJ-KQ172 Human 348 Details Get a Quote
LDLR Knockout HEK293 Cell Line EDJ-KQ273 Human 3949 Details Get a Quote
APOA1 Knockout HEK293 Cell Line EDJ-KQ1462 Human 335 Details Get a Quote
APOB Knockout HEK293 Cell Line EDJ-KQ2190 Human 338 Details Get a Quote
SCARB1 Knockout HEK293 Cell Line EDJ-KQ2450 Human 949 Details Get a Quote
ABCG1 Knockout HEK293 Cell Line EDJ-KQ3171 Human 9619 Details Get a Quote
APOA2 Knockout HEK293 Cell Line EDJ-KQ4066 Human 336 Details Get a Quote
LPL Knockout HEK293 Cell Line EDJ-KQ5140 Human 4023 Details Get a Quote
ABCA1 Knockout HEK293 Cell Line EDJ-KQ12244 Human 19 Details Get a Quote
SCARB1 Knockout A-549 Cell Line EDJ-KQ22977 Human 949 Details Get a Quote
SCARB1 Knockout HCT 116 Cell Line EDJ-KQ22978 Human 949 Details Get a Quote
SCARB1 Knockout HeLa Cell Line EDJ-KQ22979 Human 949 Details Get a Quote
APOA2 Knockout HCT 116 Cell Line EDJ-KQ25098 Human 336 Details Get a Quote
LPL Knockout HeLa Cell Line EDJ-KQ28102 Human 4023 Details Get a Quote
ABCA1 Knockout A-549 Cell Line EDJ-KQ41017 Human 19 Details Get a Quote
Displaying Records 1 To 15 Of 47 Records
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