Immunology
Enhancing T Cell Immunotherapy with CRISPR
From Conventional CAR Design to Precision-Engineered Cell Therapies
CAR-T therapy has shown remarkable success, particularly in hematological malignancies. However, traditional approaches rely on random integration, leading to variability in expression and safety concerns.
As CRISPR integrates with high-throughput screening and multiplex editing, next-generation CAR-T therapies are expected to achieve higher efficacy, safety, and adaptability.
End-to-End Workflow for T Cell Engineering
| Dimension | Key Question | Strategy | Product/Service |
| Gene Knockout | Which genes regulate or limit T cell function? | CRISPR-mediated KO | KO cell lines & custom KO services |
| Gene Knock-In | How to introduce new functions? | Targeted KI (CAR, mutations) | Knock-in services |
| CRISPR Screening | Which genes systematically control T cell activity? | CRISPR library screening | CRISPR libraries & screening services |
Built for Precision and Speed
Advanced Gene Editing Platforms
Integrating HES-KI and CRISPR-EDITx, our advanced platforms deliver efficient and reliable solutions for diverse gene editing needs.
Extensive KO Cell Line Library
Covering a wide range of genes, our extensive KO cell line library supports systematic loss-of-function studies across various disease models.
Fast Turnaround for Custom Models
With a turnaround time as short as 4 weeks for custom models, we significantly reduce project waiting time and accelerate your research.
Monoclonal Validation with Sequencing Confirmation
Monoclonal selection combined with sequencing confirmation ensures accuracy and reproducibility for every editing outcome.
Global Project Support and Delivery
Backed by a mature global project collaboration and logistics system, we provide full-process support from technical consultation to final delivery.
Experienced Team
Expert team with over 1000 gene editing projects and experience across 300+ cell types.
