Overview
Neuroinflammation
Study microglial and astrocyte activation, inflammatory mediator release and neuroinflammatory mechanisms in CNS diseases using CRISPR-engineered cell models.
What is Neuroinflammation ?
Neuroinflammation is the inflammatory response within the brain and spinal cord, driven by microglia, astrocytes and infiltrating immune cells. Chronic neuroinflammation contributes to neurodegeneration, multiple sclerosis and neuropathic pain. Modulating glial reactivity is a promising therapeutic approach.
Key Research Applications
Microglial phagocytosis/activation assays
Astrocyte reactivity profiling
NLRP3 inflammasome neuroinflammation models
Cytokine release from glial cultures
Neuroinflammatory gene knockout screening
Products
Featured/Popular Targets
ALL
TNF
IL1B
IL6
TGFB1
TGFB2
NFKB2
RELA
TLR2
TLR4
TREM2
SIGMAR1
Product name Cat.No. Species Gene ID
Trem2 Knockout BV-2 Cell Line EDC07598 Mouse 83433 Details Get a Quote
IL1B Knockout HEK293 Cell Line EDJ-KQ140 Human 3553 Details Get a Quote
IL6 Knockout HEK293 Cell Line EDJ-KQ498 Human 3569 Details Get a Quote
NFKB2 Knockout HEK293 Cell Line EDJ-KQ579 Human 4791 Details Get a Quote
RELA Knockout HEK293 Cell Line EDJ-KQ588 Human 5970 Details Get a Quote
TREM2 Knockout HEK293 Cell Line EDJ-KQ1140 Human 54209 Details Get a Quote
TLR4 Knockout HEK293 Cell Line EDJ-KQ1491 Human 7099 Details Get a Quote
SIGMAR1 Knockout HEK293 Cell Line EDJ-KQ15261 Human 10280 Details Get a Quote
TNF Knockout HEK293 Cell Line EDJ-KQ17672 Human 7124 Details Get a Quote
TGFB1 Knockout HEK293 Cell Line EDJ-KQ17770 Human 7040 Details Get a Quote
TGFB2 Knockout HEK293 Cell Line EDJ-KQ17771 Human 7042 Details Get a Quote
TLR2 Knockout HEK293 Cell Line EDJ-KQ17909 Human 7097 Details Get a Quote
TREM2 Overexpression BV-2 Stable Cell Line EDC90074 Mouse 54209 Details Get a Quote
TLR2 Knockout A-549 Cell Line EDC90495 Human 7097 Details Get a Quote
SIGMAR1 Knockout A-549 Cell Line EDJ-KQ18095 Human 10280 Details Get a Quote
Displaying Records 1 To 15 Of 67 Records
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