Overview
Immune Checkpoints
Study immune checkpoint receptor/ligand interactions, T cell exhaustion and immune checkpoint inhibitor mechanisms using CRISPR-engineered immune and tumor cell models.
What is Immune Checkpoints ?
Immune checkpoints are regulatory pathways that maintain self-tolerance and modulate the amplitude of immune responses. Tumors exploit checkpoints like PD-1/PD-L1 and CTLA-4 to evade immune attack. Immune checkpoint inhibitors have revolutionized cancer therapy, and CRISPR screens identify novel checkpoint molecules and resistance mechanisms.
Key Research Applications
PD-1/PD-L1 pathway component knockout
Checkpoint inhibitor resistance screening
T cell exhaustion reversal studies
Novel immune checkpoint discovery
B7/CD28 family receptor functional analysis
Products
Featured/Popular Targets
ALL
CD274
CTLA4
CD276
CD70
TNFRSF9
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD274 Knockout HEK293 Cell Line | EDC07777 | Human | 29126 | Details Get a Quote |
| CD276 Knockout HEK293 Cell Line | EDJ-KQ12832 | Human | 80381 | Details Get a Quote |
| CTLA4 Knockout HEK293 Cell Line | EDC07546 | Human | 1493 | Details Get a Quote |
| CD70 Knockout HEK293 Cell Line | EDC07537 | Human | 970 | Details Get a Quote |
| TNFRSF9 Knockout HEK293 Cell Line | EDC07594 | Human | 3604 | Details Get a Quote |
| CD274 Knockout A-549 Cell Line | EDJ-KQ41970 | Human | 29126 | Details Get a Quote |
| CD274 Knockout HCT 116 Cell Line | EDC07704 | Human | 29126 | Details Get a Quote |
| CD276 Knockout A-549 Cell Line | EDJ-KQ41972 | Human | 80381 | Details Get a Quote |
| CD276 Knockout HCT 116 Cell Line | EDJ-KQ41973 | Human | 80381 | Details Get a Quote |
| CD276 Knockout HeLa Cell Line | EDJ-KQ41974 | Human | 80381 | Details Get a Quote |
| CD70 Knockout A-549 Cell Line | EDJ-KQ18455 | Human | 970 | Details Get a Quote |
| TNFRSF9 Knockout A-549 Cell Line | EDJ-KQ18483 | Human | 3604 | Details Get a Quote |
| CD70 Knockout HeLa Cell Line | EDJ-KQ19790 | Human | 970 | Details Get a Quote |
| CD274 Knockout HeLa Cell Line | EDC08222 | Human | 29126 | Details Get a Quote |
| CD276 Knockout MG-63 Cell Line | EDJ-KZ14 | Human | 80381 | Details Get a Quote |
Displaying Records 1 To 15 Of 30 Records
