Overview
Nutrient Sensing
Study cellular nutrient sensing mechanisms (mTORC1, AMPK, GCN2), their signaling outputs and roles in growth, metabolism and disease using CRISPR-engineered cell models.
What is Nutrient Sensing ?
Cells sense and respond to nutrient availability through master regulators like mTORC1 (amino acids, growth factors), AMPK (energy) and GCN2 (amino acid deprivation). These pathways coordinate anabolism and catabolism. Dysregulation drives cancer, diabetes and metabolic disorders, making nutrient sensors key drug targets.
Key Research Applications
mTORC1 lysosomal translocation assays
Amino acid deprivation response profiling
Autophagy induction analysis
Rapamycin analog sensitivity screening
Metabolic stress pathway studies
Products
Featured/Popular Targets
ALL
ULK1
EIF4EBP1
ATF4
PRKAA1
PRKAA2
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ATF4 Knockout HEK293 Cell Line | EDJ-KQ611 | Human | 468 | Details Get a Quote |
| PRKAA1 Knockout HEK293 Cell Line | EDJ-KQ860 | Human | 5562 | Details Get a Quote |
| PRKAA2 Knockout HEK293 Cell Line | EDJ-KQ861 | Human | 5563 | Details Get a Quote |
| ULK1 Knockout HEK293 Cell Line | EDJ-KQ1175 | Human | 8408 | Details Get a Quote |
| EIF4EBP1 Knockout HEK293 Cell Line | EDJ-KQ1177 | Human | 1978 | Details Get a Quote |
| ATF4 Knockout A-549 Cell Line | EDJ-KQ18171 | Human | 468 | Details Get a Quote |
| ATF4 Knockout HCT 116 Cell Line | EDJ-KQ19071 | Human | 468 | Details Get a Quote |
| ATF4 Knockout HeLa Cell Line | EDJ-KQ19072 | Human | 468 | Details Get a Quote |
| ULK1 Knockout A-549 Cell Line | EDJ-KQ18276 | Human | 8408 | Details Get a Quote |
| ULK1 Knockout HCT 116 Cell Line | EDJ-KQ18277 | Human | 8408 | Details Get a Quote |
| PRKAA1 Knockout HeLa Cell Line | EDJ-KQ18312 | Human | 5562 | Details Get a Quote |
| PRKAA2 Knockout HCT 116 Cell Line | EDJ-KQ18369 | Human | 5563 | Details Get a Quote |
| PRKAA1 Knockout A-549 Cell Line | EDJ-KQ19664 | Human | 5562 | Details Get a Quote |
| PRKAA1 Knockout HCT 116 Cell Line | EDJ-KQ19665 | Human | 5562 | Details Get a Quote |
| PRKAA2 Knockout A-549 Cell Line | EDJ-KQ19666 | Human | 5563 | Details Get a Quote |
Displaying Records 1 To 15 Of 24 Records
