Overview
Cholesterol & Steroid Metabolism
Study cholesterol biosynthesis, uptake, efflux, steroidogenesis and their roles in cellular function and disease using CRISPR-engineered cell models.
What is Cholesterol & Steroid Metabolism ?
Cholesterol is a vital membrane component and precursor for steroid hormones and bile acids. Its metabolism is tightly controlled by SREBP and LXR pathways. Dysregulated cholesterol metabolism drives cardiovascular disease, metabolic syndrome and cancer. Targeting cholesterol homeostasis offers therapeutic opportunities.
Key Research Applications
SREBP/LXR pathway studies
LDL uptake/efflux assays
Steroid hormone profiling
Lipid droplet analysis
Cancer lipogenesis target screening
Products
Featured/Popular Targets
ALL
SQLE
CYP51A1
SOAT1
LDLR
SCARB1
ABCA1
ABCG1
NPC1
NPC1L1
LIPA
SREBF1
SREBF2
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| NPC1 Knockout HEK293T Cell Line | EDJ-KQ240 | Human | 4864 | Details Get a Quote |
| LDLR Knockout HEK293 Cell Line | EDJ-KQ273 | Human | 3949 | Details Get a Quote |
| SREBF2 Knockout HEK293 Cell Line | EDJ-KQ1125 | Human | 6721 | Details Get a Quote |
| SREBF1 Knockout HEK293 Cell Line | EDJ-KQ1869 | Human | 6720 | Details Get a Quote |
| SCARB1 Knockout HEK293 Cell Line | EDJ-KQ2450 | Human | 949 | Details Get a Quote |
| SQLE Knockout HEK293 Cell Line | EDJ-KQ3102 | Human | 6713 | Details Get a Quote |
| ABCG1 Knockout HEK293 Cell Line | EDJ-KQ3171 | Human | 9619 | Details Get a Quote |
| NPC1L1 Knockout HEK293 Cell Line | EDJ-KQ3813 | Human | 29881 | Details Get a Quote |
| SOAT1 Knockout HEK293 Cell Line | EDJ-KQ5816 | Human | 6646 | Details Get a Quote |
| ABCA1 Knockout HEK293 Cell Line | EDJ-KQ12244 | Human | 19 | Details Get a Quote |
| CYP51A1 Knockout HEK293 Cell Line | EDJ-KQ13085 | Human | 1595 | Details Get a Quote |
| NPC1 Knockout HEK293 Cell Line | EDJ-KQ14457 | Human | 4864 | Details Get a Quote |
| LIPA Knockout HEK293 Cell Line | EDJ-KQ17862 | Human | 3988 | Details Get a Quote |
| SCARB1 Knockout A-549 Cell Line | EDJ-KQ22977 | Human | 949 | Details Get a Quote |
| SCARB1 Knockout HCT 116 Cell Line | EDJ-KQ22978 | Human | 949 | Details Get a Quote |
Displaying Records 1 To 15 Of 64 Records
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