ABCA1 Knockout THP-1 Cell Line
Cat.No.:
EDJ-KZ519
Species:
Human
Cell Name:
THP-1
Gene:
ABCA1
Gene ID:
19
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ519 |
|---|---|
| Product Name | ABCA1 Knockout THP-1 Cell Line |
| Cell Line | THP-1 |
| Cellosaurus ID | CVCL_0006 |
| Cell Line Synonyms | THP1, THP 1, THPI, THP-1(ATCC), THP-1-O, O-THP-1, Tohoku Hospital Pediatrics-1 |
| Gene | ABCA1 |
| Gene Synonyms | ABC-1|ABC1|CERP|HDLCQTL13|HDLDT1|HPALP1|TGD |
| Summary |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019]
|
| Associated Diseases | Acute Myeloid Leukemia |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: THP-1 | STR Info (Cell bank) Cell Line: THP-1 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | Y | X | Y |
| CSF1PO | 11 | 13 | 11 | 13 |
| D1S1656 | 16 | 17 | 16 | 17 |
| D2S1338 | 17 | 18 | 17 | 18 |
| D3S1358 | 15 | 17 | 15 | 17 |
| D5S818 | 11 | 12 | 11 | 12 |
| D7S820 | 10 | 10 | ||
| D8S1179 | 10 | 14 | 10 | 14 |
| D12S391 | 19 | 18 | 19 | |
| D13S317 | 13 | 13 | ||
| D16S539 | 11 | 12 | 11 | 12 |
| D18S51 | 13 | 14 | 13 | 14 |
| D19S433 | 12.2 | 13 | 12.2 | 13 |
| D21S11 | 30 | 31.2 | 30 | 31.2 |
| FGA | 24 | 25 | 24 | 25 |
| Penta D | 10 | 12 | 10 | 12 |
| Penta E | 11 | 15 | 11 | 15 |
| TH01 | 8 | 9.3 | 8 | 9.3 |
| TPOX | 8 | 11 | 8 | 11 |
| VWA | 16 | 16 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Related Publications
E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1.
IF=13.6
The Journal of clinical investigation
Ca3.1 T-type calcium channel blocker NNC 55-0396 reduces atherosclerosis by increasing cholesterol efflux.
IF=5.6
Biochemical pharmacology
TNFAIP1 promotes macrophage lipid accumulation and accelerates the development of atherosclerosis through the LEENE/FoxO1/ABCA1 pathway.
IF=4.3
Journal of physiology and biochemistry
This KO model may be useful for:
- Studying the role of ABCA1 in macrophage cholesterol efflux and reverse cholesterol transport
- Investigating post-translational regulation of ABCA1, including ubiquitination and degradation pathways
- Evaluating the impact of ion channel modulators on ABCA1-mediated lipid metabolism
- Screening therapeutic agents for atherosclerosis targeting ABCA1 expression or function
- Exploring molecular mechanisms linking cholesterol efflux to foam cell formation and vascular inflammation
Required Accessories
Cell Culture Optimization Series
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