ABCA1 Knockout ARPE-19 Cell Line
Cat.No.:
EDJ-KZ293
Species:
Human
Cell Name:
ARPE-19
Gene:
ABCA1
Gene ID:
19
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ293 |
|---|---|
| Product Name | ABCA1 Knockout ARPE-19 Cell Line |
| Cell Line | ARPE-19 |
| Cellosaurus ID | CVCL_0145 |
| Cell Line Synonyms | ARPE19, Adult Retinal Pigment Epithelial cell line-19, NTC-200, NTC200 |
| Gene | ABCA1 |
| Gene Synonyms | ABC-1|ABC1|CERP|HDLCQTL13|HDLDT1|HPALP1|TGD |
| Summary |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency. [provided by RefSeq, Sep 2019]
|
| Associated Diseases | Non-tumor |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: ARPE-19 | STR Info (Cell bank) Cell Line: ARPE-19 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | Y | X | Y |
| CSF1PO | 11 | 11 | ||
| D2S1338 | 19 | 19 | ||
| D3S1358 | 14 | 15 | 14 | 15 |
| D5S818 | 13 | 13 | ||
| D7S820 | 9 | 11 | 9 | 11 |
| D8S1179 | 13 | 13 | ||
| D13S317 | 11 | 12 | 11 | 12 |
| D16S539 | 9 | 11 | 9 | 11 |
| D18S51 | 12 | 16 | 12 | 16 |
| D19S433 | 12 | 13 | 12 | 13 |
| D21S11 | 28 | 29 | 28 | 29 |
| FGA | 23 | 23 | ||
| Penta D | 11 | 13 | 11 | 13 |
| Penta E | 7 | 11 | 7 | 11 |
| TH01 | 6 | 9.3 | 6 | 9.3 |
| TPOX | 9 | 11 | 9 | 11 |
| vWA | 16 | 19 | 16 | 19 |
| D6S1043 | 17 | 19 | 17 | 19 |
| D12S391 | 21 | 22 | 21 | 22 |
| D2S441 | 10 | 15 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Required Accessories
Cell Culture Optimization Series
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