GPRC6A
G Protein-Coupled Receptor Class C Group 6 Member A
Gene Information Card
| Symbol | GPRC6A |
|---|---|
| Full Name | G protein-coupled receptor class C group 6 member A |
| Gene Type | protein-coding |
| Chromosomal Location | 6q22.33 |
| NCBI Gene ID | 222545 ncbi.nlm.nih.gov/gene/222545 |
| Ensembl ID | ENSG00000173674 |
| UniProt ID | Q5T6X5 |
| OMIM ID | 611246 |
| HGNC ID | 24810 |
| Aliases | GPRC6, GPCR6A |
Description
GPRC6A is a member of the class C G protein-coupled receptor family, which includes receptors for amino acids, calcium, and pheromones. It functions as a multimodal sensor for L-amino acids, calcium ions, and osteocalcin, playing roles in energy metabolism, bone remodeling, and male fertility. The gene is located on chromosome 6q22.33 and encodes a 7-transmembrane domain receptor.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Osteoporosis | GPRC6A mediates osteocalcin signaling; loss-of-function variants may impair bone formation | PMID: 21880753 |
| Metabolic syndrome | Receptor activation by amino acids and calcium influences insulin secretion and glucose homeostasis | PMID: 24711453 |
| Male infertility | GPRC6A knockout mice exhibit reduced testosterone and impaired spermatogenesis | PMID: 17974916 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Bone marrow | 8.2 | Low |
| Kidney | 6.1 | Low |
| Liver | 4.3 | Low |
| Pancreas | 3.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| HepG2 | 1.2 | Low expression |
| MCF7 | 0.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Cys) | Missense | <0.01% | Reduced calcium sensitivity |
| c.1543G>A (p.Gly515Ser) | Missense | <0.01% | Altered ligand binding |
Mutation functional classification
Loss of Function (LOF)
p.Arg339Cys reduces receptor activation by calcium and osteocalcin.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • calcium ion binding |
| • amino acid binding | • plasma membrane |
| • signal transduction |
Pathways
• GPCR downstream signaling
• Osteocalcin signaling pathway
Protein Summary
GPRC6A is a 7-transmembrane G protein-coupled receptor that senses extracellular L-amino acids, calcium ions, and osteocalcin. It activates Gq/11 and Gi/o pathways, leading to intracellular calcium mobilization and MAPK signaling. The receptor is implicated in bone metabolism, energy balance, and reproductive function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| GPRC6A Knockout HEK293 Cell Line | EDJ-KQ9019 | Human | 222545 | Details Get a Quote |
| GPRC6A Knockout HeLa Cell Line | EDJ-KQ59189 | Human | 222545 | Details Get a Quote |
| GPRC6A Knockout A-549 Cell Line | EDJ-KQ67658 | Human | 222545 | Details Get a Quote |
| GPRC6A Knockout HCT 116 Cell Line | EDJ-KQ76045 | Human | 222545 | Details Get a Quote |
| Gprc6a Knockout AML12 Cell Line | EDC07604 | Mouse | 210198 | Details Get a Quote |
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