CD99L2
CD99 Molecule Like 2
Gene Information Card
| Symbol | CD99L2 |
|---|---|
| Full Name | CD99 Molecule Like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 83692 ncbi.nlm.nih.gov/gene/83692 |
| Ensembl ID | ENSG00000102144 |
| UniProt ID | Q8TCZ2 |
| OMIM ID | 300697 |
| HGNC ID | 18237 |
| Aliases | MIC2L1, CD99 antigen-like 2 |
Description
CD99L2 (CD99 Molecule Like 2) is a protein-coding gene located on chromosome Xq28. It encodes a cell surface glycoprotein belonging to the CD99 family, involved in cell adhesion, migration, and immune cell interactions. The protein is structurally similar to CD99 and plays a role in leukocyte extravasation and T-cell activation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | Not applicable |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Bone marrow | 8.2 | Medium |
| Lung | 6.1 | Low |
| Small intestine | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | High expression |
| Jurkat | 12.1 | High expression |
| HeLa | 8.7 | Medium expression |
| K562 | 6.4 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown functional effect |
| c.100C>T | synonymous | <0.1% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion | • cell migration |
| • protein homodimerization activity | • integral component of membrane |
Pathways
• Leukocyte transendothelial migration
• Cell adhesion molecules (CAMs)
Protein Summary
CD99L2 is a transmembrane glycoprotein that shares structural homology with CD99. It is expressed on hematopoietic cells and endothelial cells, mediating cell-cell adhesion and leukocyte migration. The protein may also play a role in T-cell activation and immune surveillance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CD99L2 Knockout HEK293 Cell Line | EDJ-KQ9884 | Human | 83692 | Details Get a Quote |
| CD99L2 Knockout A-549 Cell Line | EDJ-KQ36759 | Human | 83692 | Details Get a Quote |
| CD99L2 Knockout HCT 116 Cell Line | EDJ-KQ36760 | Human | 83692 | Details Get a Quote |
| CD99L2 Knockout HeLa Cell Line | EDJ-KQ36761 | Human | 83692 | Details Get a Quote |
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