CCNL2
Cyclin L2: A regulator of transcription and splicing with roles in cell cycle and cancer
Gene Information Card
| Symbol | CCNL2 |
|---|---|
| Full Name | Cyclin L2 |
| Gene Type | Protein coding |
| Chromosomal Location | 1p36.33 |
| NCBI Gene ID | 81669 ncbi.nlm.nih.gov/gene/81669 |
| Ensembl ID | ENSG00000142627 |
| UniProt ID | Q96S94 |
| OMIM ID | 613754 |
| HGNC ID | 20569 |
| Aliases | CCNL2, cyclin L2, ania-6b, hCycL2 |
Description
CCNL2 encodes cyclin L2, a member of the cyclin family involved in regulating transcription and pre-mRNA splicing. The protein contains a cyclin domain and an arginine/serine-rich (RS) region, localizes to nuclear speckles, and interacts with RNA polymerase II and splicing factors. CCNL2 is implicated in cell cycle control, differentiation, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression and splicing regulation | COSMIC, literature |
| Hepatocellular carcinoma | Upregulation promotes proliferation | PubMed |
| Breast cancer | Overexpression linked to poor prognosis | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Bone marrow | 10.5 | Medium |
| Brain | 8.3 | Low |
| Liver | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 18.4 | High expression |
| HeLa | 14.7 | Medium expression |
| MCF7 | 11.2 | Medium expression |
| HepG2 | 9.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| p.R126Q | Missense | <0.1% | Unknown functional impact |
| p.S187L | Missense | <0.1% | Unknown functional impact |
| c.456+1G>A | Splice site | <0.1% | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Splice site mutations may lead to loss of function.
Gain of Function (GOF)
Not well characterized.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • nucleus (GO:0005634) | • regulation of transcription by RNA polymerase II (GO:0006357) |
| • mRNA processing (GO:0006397) | • RNA splicing (GO:0008380) |
| • protein binding (GO:0005515) |
Pathways
• RNA splicing (Reactome: R-HSA-72163)
• Processing of Capped Intron-Containing Pre-mRNA (Reactome: R-HSA-72203)
Protein Summary
Cyclin L2 is a 58 kDa protein with a cyclin domain and an RS-rich region. It localizes to nuclear speckles and interacts with splicing factors and RNA polymerase II, modulating transcription elongation and alternative splicing. The protein is expressed in multiple tissues and is upregulated in certain cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCNL2 Knockout HEK293 Cell Line | EDC90276 | Human | 81669 | Details Get a Quote |
| CCNL2 Knockout A-549 Cell Line | EDJ-KQ22862 | Human | 81669 | Details Get a Quote |
| CCNL2 Knockout HCT 116 Cell Line | EDJ-KQ22863 | Human | 81669 | Details Get a Quote |
| CCNL2 Knockout HeLa Cell Line | EDC90277 | Human | 81669 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
