MS4A15
Membrane Spanning 4-Domains A15
Gene Information Card
| Symbol | MS4A15 |
|---|---|
| Full Name | Membrane Spanning 4-Domains A15 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.2 |
| NCBI Gene ID | 219738 ncbi.nlm.nih.gov/gene/219738 |
| Ensembl ID | ENSG00000166965 |
| UniProt ID | Q96PJ5 |
| OMIM ID | 615447 |
| HGNC ID | 16620 |
| Aliases | CD20-L4, MS4A14 |
Description
MS4A15 (Membrane Spanning 4-Domains A15) is a protein-coding gene located on chromosome 11q12.2. It belongs to the membrane-spanning 4A gene family, which includes CD20 (MS4A1) and other members involved in immune cell signaling and calcium flux. The encoded protein is predicted to be a multi-pass membrane protein with four transmembrane domains. Its specific biological function remains under investigation, but it is thought to play a role in B-cell development or immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 0.0 | Not detected |
| Spleen | 0.0 | Not detected |
| Whole blood | 0.0 | Not detected |
| Testis | 0.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.0 | Not expressed |
| K562 | 0.0 | Not expressed |
| MCF7 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No known loss-of-function variants reported.
Gain of Function (GOF)
No known gain-of-function variants reported.
Dominant Negative (DN)
No known dominant-negative variants reported.
View complete mutation data：
Protein Summary
The MS4A15 protein (UniProt Q96PJ5) is a predicted multi-pass membrane protein with four transmembrane domains. It belongs to the membrane-spanning 4A family, which includes CD20. The exact function is unknown, but it may be involved in calcium signaling or immune cell regulation. No experimental protein structure or functional data are currently available.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MS4A15 Knockout HEK293 Cell Line | EDJ-KQ8483 | Human | 219995 | Details Get a Quote |
| MS4A15 Knockout HCT 116 Cell Line | EDJ-KQ34598 | Human | 219995 | Details Get a Quote |
| MS4A15 Knockout HeLa Cell Line | EDJ-KQ59128 | Human | 219995 | Details Get a Quote |
| MS4A15 Knockout A-549 Cell Line | EDJ-KQ67602 | Human | 219995 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
