MS4A13
Membrane Spanning 4-Domains A13
Gene Information Card
| Symbol | MS4A13 |
|---|---|
| Full Name | Membrane Spanning 4-Domains A13 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.1 |
| NCBI Gene ID | 503628 ncbi.nlm.nih.gov/gene/503628 |
| Ensembl ID | ENSG00000197980 |
| UniProt ID | Q96JQ5 |
| OMIM ID | 615531 |
| HGNC ID | 26679 |
| Aliases | CD20-L4, MS4A13A |
Description
MS4A13 (Membrane Spanning 4-Domains A13) is a protein-coding gene located on chromosome 11q12.1. It belongs to the membrane-spanning 4A gene family, which includes CD20 and Fc receptor beta subunit. The encoded protein is predicted to be a multi-pass membrane protein involved in signal transduction and immune regulation. Expression is primarily in lymphoid tissues and the brain.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 5.2 | Low |
| Spleen | 4.8 | Low |
| Brain (cerebellum) | 3.1 | Low |
| Testis | 2.5 | Not detected |
| Lung | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.5 | Low expression |
| K562 | 0.3 | Low expression |
| HeLa | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane | • integral component of membrane |
| • signal transduction |
Pathways
• No curated pathways
Protein Summary
MS4A13 encodes a 4-transmembrane domain protein of the MS4A family. The protein is predicted to localize to the plasma membrane and may function in immune cell signaling. No functional studies have been published, and its biological role remains unclear.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MS4A13 Knockout HEK293 Cell Line | EDJ-KQ14314 | Human | 503497 | Details Get a Quote |
| MS4A13 Knockout HeLa Cell Line | EDJ-KQ60488 | Human | 503497 | Details Get a Quote |
| MS4A13 Knockout A-549 Cell Line | EDJ-KQ68958 | Human | 503497 | Details Get a Quote |
| MS4A13 Knockout HCT 116 Cell Line | EDJ-KQ77316 | Human | 503497 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
