MS4A10 Gene - Membrane Spanning 4-Domains A10
MS4A10: A member of the MS4A family with potential roles in immune signaling and cancer
Gene Information Card
| Symbol | MS4A10 |
|---|---|
| Full Name | Membrane Spanning 4-Domains A10 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.2 |
| NCBI Gene ID | 341116 ncbi.nlm.nih.gov/gene/341116 |
| Ensembl ID | ENSG00000149476 |
| UniProt ID | Q96PG0 |
| OMIM ID | 613534 |
| HGNC ID | 13371 |
| Aliases | CD20-L4, MS4A10, 4SPAN10 |
Description
MS4A10 (Membrane Spanning 4-Domains A10) is a protein-coding gene belonging to the MS4A family, which includes CD20 (MS4A1) and other tetraspanin-like proteins. The encoded protein is predicted to span the membrane four times and may function in signal transduction, immune regulation, or ion transport. MS4A10 is expressed in various tissues and has been implicated in certain cancers and immune-related conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Altered expression; potential role in tumor progression | COSMIC; limited evidence |
| Breast Cancer | Differential expression observed; mechanism unclear | COSMIC; limited evidence |
| Immune System Diseases | Possible involvement in B-cell signaling (family homology) | Inferred from family function |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 5.2 | Medium |
| Spleen | 3.8 | Low |
| Bone Marrow | 2.1 | Low |
| Testis | 1.5 | Low |
| Brain | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 6.1 | Moderate expression |
| MCF7 (breast cancer) | 4.3 | Low expression |
| K562 (leukemia) | 2.7 | Low expression |
| HEK293 (embryonic kidney) | 1.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.1% | Unknown; likely benign |
| c.350T>C (p.Leu117Pro) | Missense | <0.1% | Unknown; predicted possibly damaging |
| c.500_501insA | Frameshift | <0.1% | Loss of function predicted |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.500_501insA) are predicted to cause loss of function via premature truncation.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • plasma membrane | • integral component of membrane |
| • signal transduction | • protein binding |
Pathways
• MS4A family signaling (inferred)
• B-cell receptor signaling (inferred from family)
Protein Summary
The MS4A10 protein is a 4-transmembrane domain protein of approximately 25 kDa. It shares structural homology with CD20 and other MS4A family members, suggesting a role in cell surface signaling or ion transport. Expression data indicate moderate levels in lung and spleen, with lower levels in other tissues. Functional studies are limited, but the protein may be involved in immune cell modulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| MS4A10 Knockout HEK293 Cell Line | EDJ-KQ8592 | Human | 341116 | Details Get a Quote |
| MS4A10 Knockout HeLa Cell Line | EDJ-KQ59701 | Human | 341116 | Details Get a Quote |
| MS4A10 Knockout A-549 Cell Line | EDJ-KQ68174 | Human | 341116 | Details Get a Quote |
| MS4A10 Knockout HCT 116 Cell Line | EDJ-KQ76549 | Human | 341116 | Details Get a Quote |
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