TRAF2 Gene: Function, Mutations, and Disease Associations | Biomedical SEO

TRAF2 (TNF receptor-associated factor 2) encodes a member of the TNF receptor-associated factor (TRAF) protein family. TRAF2 is a critical adaptor protein that mediates signal transduction from TNF receptors (TNFR1 and TNFR2) and other receptors, leading to activation of NF-κB and MAPK pathways. It plays a key role in regulating inflammation, apoptosis, and immune responses. TRAF2 contains a RING finger domain, zinc finger domains, and a TRAF domain, which mediate protein-protein interactions and ubiquitin ligase activity.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• TNF signaling pathway

• NF-κB signaling pathway

• MAPK signaling pathway

• Apoptosis

• RIG-I-like receptor signaling pathway

TRAF2 is a 501-amino acid protein with a molecular weight of approximately 56 kDa. It contains a RING finger domain (residues 1-100), two zinc finger domains (residues 100-200), and a TRAF domain (residues 300-501) that mediates trimerization and interaction with receptors. TRAF2 functions as an E3 ubiquitin ligase, catalyzing K63-linked polyubiquitination of itself and other substrates, leading to activation of TAK1 and IKK complexes, ultimately activating NF-κB. It also interacts with cIAP1/2 to regulate apoptosis.