pU6-CTNNB1-pegRNA-sgRNA-Puro
EDITGENE guarantees pU6-CTNNB1-pegRNA-sgRNA-Puro has passed QC, endotoxin-free, and project validated. more
Cat.No: EDV456
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EDITGENE guarantees pU6-CTNNB1-pegRNA-sgRNA-Puro has passed QC, endotoxin-free, and project validated.
| Plasmid Resistance | Amp |
|---|---|
| Type | PE |
| Selection Marker | Puro |
| Gene ID | |
| Gene | CTNNB1 |
| Gene Synonyms | CTNNB|EVR7|MRD19|NEDSDV|armadillo |
| Summary |
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
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* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
Storage
Store at -20 ºC for short term. -80 ºC for long term preservation.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
