lentiCRISPR v2-SREBF1-sgRNA1-puro
EDITGENE guarantees lentiCRISPR v2-SREBF1-sgRNA1-puro plasmid has passed QC, endotoxin-free, and project validated. more
Cat.No: EDV152
Quantity
EDITGENE guarantees lentiCRISPR v2-SREBF1-sgRNA1-puro plasmid has passed QC, endotoxin-free, and project validated.
| Plasmid Resistance | Amp |
|---|---|
| Type | KO |
| Selection Marker | Puro |
| Tag | / |
| Gene ID | |
| Gene | SREBF1 |
| Gene Synonyms | HMD|IFAP2|SREBP1|bHLHd1 |
| Summary |
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
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* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
Storage
Store at -20 ºC for short term. -80 ºC for long term preservation.
