lentiCRISPR v2-PTAFR-sgRNA2-puro
EDITGENE guarantees lentiCRISPR v2-PTAFR-sgRNA2-puro plasmid has passed QC, endotoxin-free, and project validated. more
Cat.No: EDV151
Quantity
EDITGENE guarantees lentiCRISPR v2-PTAFR-sgRNA2-puro plasmid has passed QC, endotoxin-free, and project validated.
| Plasmid Resistance | Amp |
|---|---|
| Type | KO |
| Selection Marker | puro |
| Tag | / |
| Gene ID | |
| Gene | PTAFR |
| Gene Synonyms | PAFR |
| Summary |
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
|
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
Storage
Store at -20 ºC for short term. -80 ºC for long term preservation.
