PINK1 Knockout HeLa Cell Line
Cat.No.:
EDJ-KQ25147
Species:
Human
Cell Name:
HeLa
Gene:
PINK1
Gene ID:
65018
Size:
1×10⁶cells
PINK1 Knockout Cell Line (Hela) is an exclusive upgraded CRISPR/Cas9 system-mediated gene knockout cell, with the advantages of Optimized Strategy Design, Efficient Cell Transfection, High-Performance Cas9 Protein and Hassle-Free Cell Selection.
| Cat.No. | EDJ-KQ25147 |
|---|---|
| Product Name | PINK1 Knockout Hela Cell Line |
| Cell Line | Hela |
| Cellosaurus ID | CVCL_0030 |
| Cell Line Synonyms | HELA, Hela, He La, He-La, HeLa-CCL2, Henrietta Lacks cells, Helacyton gartleri |
| Gene | PINK1 |
| NCBI Gene ID | |
| Gene Synonyms | BRPK|PARK6 |
| Summary |
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]
|
| Associated Diseases | Cervical Carcinoma |
| Morphology | Adherent |
| Passage Ratio | 1/5, 2days |
| Complete Culture Medium | MEM + 10% FBS |
| Freezing Medium | 70%Complete culture medium+ 20% FBS+ 10% DMSO |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: HeLa | STR Info (Cell bank) Cell Line: HeLa | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | X | ||
| CSF1PO | 9 | 10 | 9 | 10 |
| D1S1656 | 12 | 15 | 12 | 15 |
| D2S1338 | 17 | 17 | ||
| D3S1358 | 15 | 18 | 15 | 18 |
| D5S818 | 11 | 12 | 11 | 12 |
| D6S1043 | 18 | 18 | ||
| D7S820 | 8 | 12 | 8 | 12 |
| D8S1179 | 12 | 13 | 12 | 13 |
| D12S391 | 20 | 25 | 20 | 25 |
| D13S317 | 12 | 14 | 12 | 14 |
| D16S539 | 9 | 10 | 9 | 10 |
| D18S51 | 16 | 16 | ||
| D19S433 | 13 | 14 | 13 | 14 |
| D21S11 | 27 | 28 | 27 | 28 |
| FGA | 18 | 21 | 18 | 21 |
| Penta D | 8 | 15 | 8 | 15 |
| Penta E | 7 | 17 | 7 | 17 |
| TPOX | 8 | 12 | 8 | 12 |
| VWA | 16 | 18 | 16 | 18 |
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Related Publications
Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy.
IF=14.3
Autophagy
Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues.
IF=6.9
Cell reports
A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy.
IF=6.4
The Journal of cell biology
TBK1 adaptor AZI2/NAP1 regulates NDP52-driven mitochondrial autophagy.
IF=3.9
The Journal of biological chemistry
Parkin-dependent mitophagy occurs via proteasome-dependent steps sequentially targeting separate mitochondrial sub-compartments for autophagy.
Autophagy reports
This KO model may be useful for:
- Investigating Parkin-dependent mitophagy and proteasome-mediated mitochondrial sub-compartment degradation
- Studying interorganelle communication and autophagy via MFN1/MFN2 endogenous interactomes
- Elucidating TBK1 adaptor (AZI2/NAP1) and NDP52-driven mitochondrial autophagy pathways
- Characterizing RAB7A phosphoswitch and Rubicon Homology protein regulation in mitophagy
- Exploring PINK1 signaling antagonism, PKR-dependent inflammation, and viral invasion mechanisms (e.g., ZIKV)
Recommended Accessories
Cell Culture Optimization Series
Related Products
CRISPR Knockout Kit
Flash CRISPR Knockout Kit（Universal Version）Flash CRISPR Knockout Kit（Universal Version）
Flash-Pro CRISPR KO Kit (For Organoids / Stem Cells)Flash-Pro CRISPR KO Kit (For Organoids / Stem Cells)
