GSDMD Knockout THP-1 Cell Line
Cat.No.:
EDJ-KZ274
Species:
Human
Cell Name:
THP-1
Gene:
GSDMD
Gene ID:
79792
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ274 |
|---|---|
| Product Name | GSDMD Knockout THP-1 Cell Line |
| Cell Line | THP-1 |
| Cellosaurus ID | CVCL_0006 |
| Cell Line Synonyms | THP1, THP 1, THPI, THP-1(ATCC), THP-1-O, O-THP-1, Tohoku Hospital Pediatrics-1 |
| Gene | GSDMD |
| Gene Synonyms | DF5L|DFNA5L|FKSG10|GSDMDC1 |
| Summary |
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
|
| Associated Diseases | Acute Myeloid Leukemia |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: THP-1 | STR Info (Cell bank) Cell Line: THP-1 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | Y | X | Y |
| CSF1PO | 11 | 13 | 11 | 13 |
| D1S1656 | 16 | 17 | 16 | 17 |
| D2S1338 | 17 | 18 | 17 | 18 |
| D3S1358 | 15 | 17 | 15 | 17 |
| D5S818 | 11 | 12 | 11 | 12 |
| D7S820 | 10 | 10 | ||
| D8S1179 | 10 | 14 | 10 | 14 |
| D12S391 | 19 | 18 | 19 | |
| D13S317 | 13 | 13 | ||
| D16S539 | 11 | 12 | 11 | 12 |
| D18S51 | 13 | 14 | 13 | 14 |
| D19S433 | 12.2 | 13 | 12.2 | 13 |
| D21S11 | 30 | 31.2 | 30 | 31.2 |
| FGA | 24 | 25 | 24 | 25 |
| Penta D | 10 | 12 | 10 | 12 |
| Penta E | 11 | 15 | 11 | 15 |
| TH01 | 8 | 9.3 | 8 | 9.3 |
| TPOX | 8 | 11 | 8 | 11 |
| VWA | 16 | 16 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Related Publications
Hepatic TNFRSF12A promotes bile acid-induced hepatocyte pyroptosis through NFκB/Caspase-1/GSDMD signaling in cholestasis.
IF=7
Cell death discovery
Pericentriolar material 1 promotes intestinal inflammation in ulcerative colitis by activating NLRP3/gasdermin D-mediated macrophage pyroptosis.
IF=4.2
FASEB journal : official publication of the Federation of American Societies for Experimental Biolog
Macrophages promote growth, migration and epithelial-mesenchymal transition of renal cell carcinoma by regulating GSDMD/IL-1β axis.
IF=3.7
Cytokine
Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages.
IF=3.5
Viruses
Protocol for Generation of Single-Gene Knockout in Hard-to-Transfect THP1 Cell Lines Using CRISPR/Cas9.
IF=1.1
Bio-protocol
This KO model may be useful for:
- Investigating pyroptosis and inflammasome signaling pathways (e.g., NLRP3/Caspase-1/GSDMD) in macrophages
- Studying GSDMD-mediated IL-1β secretion in tumor microenvironment and immune modulation
- Modeling bile acid- or viral glycoprotein-induced inflammatory cell death
- Functional validation of GSDMD in gastrointestinal and hepatic inflammation (e.g., cholestasis, ulcerative colitis)
- Drug screening for inhibitors of GSDMD-dependent pyroptosis in hard-to-transfect THP-1 cells
Recommended Accessories
Cell Culture Optimization Series
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