TLR3 Knockout A-431 Cell Line
Cat.No.:
EDJ-KZ510
Species:
Human
Cell Name:
A-431
Gene:
TLR3
Gene ID:
7098
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ510 |
|---|---|
| Product Name | TLR3 Knockout A-431 Cell Line |
| Cell Line | A-431 |
| Cellosaurus ID | CVCL_0037 |
| Cell Line Synonyms | A431, A431/P |
| Gene | TLR3 |
| NCBI Gene ID | |
| Gene Synonyms | CD283|IIAE2|IMD83 |
| Summary |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It thus plays a role in host defense against multiple viruses. [provided by RefSeq, Jul 2021]
|
| Associated Diseases | Other Solid Cancers |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: A-431 | STR Info (Cell bank) Cell Line: A-431 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| Amelogenin | X | X | ||
| CSF1PO | 11 | 12 | 11 | 12 |
| D5S818 | 12 | 13 | 12 | 13 |
| D7S820 | 10 | 10 | ||
| D13S317 | 9 | 13 | 9 | 13 |
| D16S539 | 12 | 14 | 12 | 14 |
| TPOX | 11 | 11 | ||
| vWA | 15 | 17 | 15 | 17 |
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
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