TBK1 Knockout HeLa Cell Line

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TBK1 Knockout HeLa Cell Line
Cat.No.:

EDJ-KQ20630

Species:

Human

Cell Name:

HeLa

Gene:

TBK1

Gene ID:

29110

Size:

1×10⁶cells

TBK1 Knockout Cell Line (Hela) is an exclusive upgraded CRISPR/Cas9 system-mediated gene knockout cell, with the advantages of Optimized Strategy Design, Efficient Cell Transfection, High-Performance Cas9 Protein and Hassle-Free Cell Selection.
Cat.No. EDJ-KQ20630
Product Name TBK1 Knockout Hela Cell Line
Cell Line Hela
Cellosaurus ID CVCL_0030
Cell Line Synonyms HELA, Hela, He La, He-La, HeLa-CCL2, Henrietta Lacks cells, Helacyton gartleri
Gene TBK1
NCBI Gene ID
Gene Synonyms AIARV|FTDALS4|IIAE8|NAK|T2K
Summary
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]
Associated Diseases Cervical Carcinoma
Morphology Adherent
Passage Ratio 1/5, 2days
Complete Culture Medium MEM + 10% FBS
Freezing Medium 70%Complete culture medium+ 20% FBS+ 10% DMSO
QC Indels validated by Sanger sequencing; sterility confirmed via microbial testing.
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
LociSTR Info (Sample Cell)
Sample Cell Line: HeLa		STR Info (Cell bank)
Cell Line: HeLa
Allele1Allele2Allele1Allele2
Amelogenin X X
CSF1PO 9 10 9 10
D1S1656 12 15 12 15
D2S1338 17 17
D3S1358 15 18 15 18
D5S818 11 12 11 12
D6S1043 18 18
D7S820 8 12 8 12
D8S1179 12 13 12 13
D12S391 20 25 20 25
D13S317 12 14 12 14
D16S539 9 10 9 10
D18S51 16 16
D19S433 13 14 13 14
D21S11 27 28 27 28
FGA 18 21 18 21
Penta D 8 15 8 15
Penta E 7 17 7 17
TPOX 8 12 8 12
VWA 16 18 16 18
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.

Related Publications

IF=15.7
Nature communications
IF=3.9
The Journal of biological chemistry
IF=3.4
Journal of immunology (Baltimore, Md. : 1950)
This KO model may be useful for: - Investigating selective autophagy pathways, including lysophagy and mitophagy, via TBK1 adaptor and receptor mechanisms. - Studying host-virus interactions, particularly SARS-CoV-2 NSP13-mediated evasion of type I IFN responses through TBK1 degradation. - Elucidating signaling cascades in lysosomal damage response and cargo receptor recruitment (e.g., TAX1BP1, NDP52). - Functional validation of TBK1-dependent innate immune signaling and its regulation by ubiquitin-autophagy axes. - Screening for modulators of TBK1-driven autophagy and antiviral immunity.

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