Cd274 Knockout MC-38 Cell Line
Cat.No.:
EDJ-KZ138
Species:
Mouse
Cell Name:
MC-38
Gene:
Cd274
Gene ID:
29126
Size:
1×10⁶cells
| Cat.No. | EDJ-KZ138 |
|---|---|
| Product Name | Cd274 Knockout MC38 Cell Line |
| Species | Mouse |
| Cell Line | MC-38 |
| Cellosaurus ID | CVCL_B288 |
| Cell Line Synonyms | MCA-38, MCA 38, MCA38, MC38, MC-38 B/6, Mouse Colon 38, Murine Carcinoma-38, Colon-38, Colon 38, Colon38, C38 |
| Gene | Cd274 |
| Gene Synonyms | ADMIO5|B7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1|hPD-L1 |
| QC | Indels validated by Sanger sequencing; sterility confirmed via microbial testing. |
* For research use only. Not intended for use in humans or animals, including clinical, therapeutic, or diagnostic purposes.
| Loci | STR Info (Sample Cell) Sample Cell Line: MC-38 | STR Info (Cell bank) Cell Line: MC-38 | ||
| Allele1 | Allele2 | Allele1 | Allele2 | |
| 1-1 | 16 | 16 | ||
| 1-2 | 19 | 19 | ||
| 2-1 | 16 | 16 | ||
| 3-2 | 13 | 14 | 13 | 14 |
| 4-2 | 20.3 | 20.3 | ||
| 5-5 | 17 | 17 | ||
| 6-4 | 18 | 18 | ||
| 6-7 | 14 | 15 | 14 | 15 |
| 7-1 | 26.2 | 26.2 | ||
| 8-1 | 16 | 17 | 16 | 17 |
| 11-2 | 16 | 16 | ||
| 12-1 | 17 | 17 | ||
| 13-1 | 17.1 | 17.1 | ||
| 15-3 | 22.3 | 22.3 | ||
| 17-2 | 15 | 15 | ||
| 18-3 | 16 | 16 | ||
| 19-2 | 13 | 13 | ||
| X-1 | 27 | 27 | ||
* STR authentication data of this cell line matches with that of cell lines sourced from ATCC, DSMZ, JCRB, and RIKEN databases.
Conclusion: The STR identification of this cell is correct.
Conclusion: The STR identification of this cell is correct.
* Research Use Disclaimer: Content is generated from publicly available research data, bioinformatic resources, and computational analyses for research reference only.
Related Publications
Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8 T-cell Responses.
IF=16.6
Cancer research
A preclinical study: correlation between PD-L1 PET imaging and the prediction of therapy efficacy of MC38 tumor with Ga-labeled PD-L1 targeted nanobody.
IF=3.9
Aging
This KO model may be useful for:
- Evaluating PD-L1-targeted imaging probes and PET tracer specificity in vivo.
- Investigating the role of tumor-intrinsic PD-L1 in modulating anti-tumor CD8+ T-cell responses.
- Mechanistic studies on PD-L1-mediated immune evasion in the tumor microenvironment.
- Preclinical validation of PD-L1-dependent therapeutic efficacy in immunotherapy models.
- Functional studies dissecting the differential roles of lymphatic versus tumor PD-L1 in immune regulation.
Required Accessories
Cell Culture Optimization Series
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