USP32: Ubiquitin Specific Peptidase 32
A deubiquitinating enzyme implicated in cancer and cellular signaling
Gene Information Card
| Symbol | USP32 |
|---|---|
| Full Name | Ubiquitin Specific Peptidase 32 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q23.2 |
| NCBI Gene ID | 84669 ncbi.nlm.nih.gov/gene/84669 |
| Ensembl ID | ENSG00000170832 |
| UniProt ID | Q8NFA0 |
| OMIM ID | 617865 |
| HGNC ID | 19140 |
| Aliases | NY-REN-60, USP10, USP32_v1 |
Description
USP32 (Ubiquitin Specific Peptidase 32) is a protein-coding gene that encodes a deubiquitinating enzyme (DUB) belonging to the ubiquitin-specific protease family. The protein removes ubiquitin from target proteins, regulating protein stability, localization, and activity. USP32 is involved in cellular processes such as endosomal trafficking, receptor signaling, and cell proliferation. It has been implicated in various cancers, including breast cancer, where it may act as an oncogene.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | USP32 amplification and overexpression promote tumor growth by stabilizing oncoproteins | COSMIC, literature |
| Lung Cancer | USP32 mutations and copy number alterations observed in non-small cell lung cancer | COSMIC |
| Ovarian Cancer | USP32 overexpression linked to poor prognosis and chemoresistance | COSMIC, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Low |
| Breast | 8.3 | Low |
| Lung | 15.2 | Medium |
| Ovary | 10.1 | Low |
| Testis | 20.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 18.5 | Moderate expression |
| A549 (lung cancer) | 22.1 | Moderate expression |
| HeLa (cervical cancer) | 15.0 | Low expression |
| HEK293 (embryonic kidney) | 12.3 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.1% | Unknown functional effect |
| c.2567_2568del (p.Gln856fs) | Frameshift | <0.1% | Predicted loss of function |
| Amplification | Copy number gain | 5-10% in breast cancer | Oncogenic activation |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to truncate the protein, impairing deubiquitinase activity.
Gain of Function (GOF)
Gene amplification and overexpression observed in cancers, suggesting oncogenic gain-of-function.
Dominant Negative (DN)
Not reported for USP32.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004843 - cysteine-type deubiquitinase activity | • GO:0006511 - ubiquitin-dependent protein catabolic process |
| • GO:0005737 - cytoplasm | • GO:0016020 - membrane |
| • GO:0036459 - thiol-dependent ubiquitinyl hydrolase activity |
Pathways
• Ubiquitin-proteasome pathway
• Endosomal trafficking
• EGFR signaling
Protein Summary
USP32 is a 1,470-amino acid deubiquitinating enzyme with a catalytic domain characteristic of ubiquitin-specific proteases. It localizes to the cytoplasm and membranes, where it removes ubiquitin from substrates, thereby regulating protein stability and signaling. USP32 is involved in endosomal sorting and receptor recycling. Its overexpression in breast cancer suggests a role in tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| USP32 Knockout HEK293 Cell Line | EDJ-KQ2225 | Human | 84669 | Details Get a Quote |
| USP32 Knockout A-549 Cell Line | EDJ-KQ22504 | Human | 84669 | Details Get a Quote |
| USP32 Knockout HCT 116 Cell Line | EDJ-KQ22505 | Human | 84669 | Details Get a Quote |
| USP32 Knockout HeLa Cell Line | EDJ-KQ22506 | Human | 84669 | Details Get a Quote |
| USP32 Knockout HAP1 Cell Line | EDC08177 | Human | 84669 | Details Get a Quote |
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