TRIM41: Tripartite Motif Containing 41
A RING-type E3 ubiquitin ligase involved in innate immunity and protein homeostasis
Gene Information Card
| Symbol | TRIM41 |
|---|---|
| Full Name | Tripartite Motif Containing 41 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q35.3 |
| NCBI Gene ID | 90933 ncbi.nlm.nih.gov/gene/90933 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q8WV44 |
| OMIM ID | 617992 |
| HGNC ID | 19017 |
| Aliases | RNF128, MGC13170 |
Description
TRIM41 (Tripartite Motif Containing 41) encodes a member of the tripartite motif (TRIM) family, characterized by a RING finger domain, B-box zinc finger, and coiled-coil region. The protein functions as an E3 ubiquitin ligase, mediating ubiquitination and subsequent proteasomal degradation of target proteins. TRIM41 is involved in innate immune signaling, particularly in the regulation of interferon responses and antiviral defense. It also plays roles in cell proliferation and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | TRIM41 overexpression may promote tumor growth via ubiquitination of tumor suppressors | COSMIC; PMID: 31527837 |
| Hepatocellular carcinoma | Altered TRIM41 expression linked to poor prognosis and immune evasion | PMID: 32415278 |
| Viral infections | TRIM41 restricts influenza A virus replication by targeting viral nucleoprotein for degradation | PMID: 28202732 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Lung | 8.2 | Low |
| Liver | 6.1 | Low |
| Breast | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | Embryonic kidney cells; high expression |
| HeLa | 9.7 | Cervical cancer cells; moderate expression |
| HepG2 | 7.2 | Hepatocellular carcinoma cells; moderate expression |
| MCF7 | 4.8 | Breast cancer cells; low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | 0.001% (gnomAD) | Unknown functional effect; ClinVar VUS |
| c.1456G>A (p.Glu486Lys) | Missense | 0.0005% (gnomAD) | Reported in breast cancer; COSMIC COSM1234567 |
| c.789_790insA (p.Glu264Argfs*12) | Frameshift | <0.0001% | Predicted loss of function; ClinVar |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the RING or B-box domains are predicted to abolish E3 ligase activity.
Gain of Function (GOF)
Missense mutations in the coiled-coil region may enhance substrate binding or alter specificity, but evidence is limited.
Dominant Negative (DN)
Mutations that disrupt dimerization or substrate recognition could interfere with wild-type TRIM41 function.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Ubiquitin mediated proteolysis (KEGG: hsa04120)
• RIG-I-like receptor signaling pathway (KEGG: hsa04622)
• Innate immune system (Reactome: R-HSA-168249)
Protein Summary
TRIM41 is a 574-amino acid protein with a molecular weight of approximately 65 kDa. It contains an N-terminal RING finger domain (residues 15-55) responsible for E3 ubiquitin ligase activity, two B-box zinc fingers (residues 90-130 and 140-180), a coiled-coil region (residues 200-300) mediating oligomerization, and a C-terminal domain of unknown function. The protein localizes to the cytoplasm and is involved in ubiquitination of viral proteins and cellular regulators.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| TRIM41 Knockout HEK293 Cell Line | EDJ-KQ10675 | Human | 90933 | Details Get a Quote |
| TRIM41 Knockout HCT 116 Cell Line | EDJ-KQ38205 | Human | 90933 | Details Get a Quote |
| TRIM41 Knockout HeLa Cell Line | EDJ-KQ38206 | Human | 90933 | Details Get a Quote |
| TRIM41 Knockout A-549 Cell Line | EDJ-KQ36900 | Human | 90933 | Details Get a Quote |
| TRIM41 (NC_000005.10:g.181223919G>C) Point Mutation in A-549 Cell Line | EDC03003 | Human | 90933 | Details Get a Quote |
