SUMO3: Small Ubiquitin-like Modifier 3
A key regulator of post-translational modification by SUMOylation, involved in nuclear transport, transcriptional regulation, and stress response.
Gene Information Card
| Symbol | SUMO3 |
|---|---|
| Full Name | Small Ubiquitin-like Modifier 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 21q22.3 |
| NCBI Gene ID | 6612 ncbi.nlm.nih.gov/gene/6612 |
| Ensembl ID | ENSG00000184922 |
| UniProt ID | P55854 |
| OMIM ID | 602231 |
| HGNC ID | 11124 |
| Aliases | SMT3A, SMT3H1, SUMO-3, Smt3A |
Description
SUMO3 encodes a member of the small ubiquitin-like modifier (SUMO) protein family. SUMO3 is conjugated to target proteins as a post-translational modification (SUMOylation) to regulate nuclear transport, transcriptional activity, DNA repair, and stress responses. SUMO3 shares high sequence similarity with SUMO2 and can form poly-SUMO chains. The gene is located on chromosome 21q22.3.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered SUMOylation of transcription factors and oncoproteins; SUMO3 overexpression may promote tumorigenesis by stabilizing oncogenic substrates. | COSMIC; PMID: 25636836 |
| Neurodegenerative disorders | Dysregulation of SUMOylation affects protein aggregation and stress granule dynamics; SUMO3 modifies tau and alpha-synuclein. | PMID: 28431233 |
| Cardiovascular disease | SUMO3 modification of ion channels and signaling proteins influences cardiac hypertrophy and ischemia-reperfusion injury. | PMID: 25986610 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Lymph node | 12.8 | Medium |
| Brain (cerebellum) | 11.5 | Medium |
| Heart | 10.1 | Medium |
| Liver | 8.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.3 | Cervical carcinoma; high expression |
| HEK293 | 13.1 | Embryonic kidney; moderate expression |
| K562 | 12.5 | Leukemia; moderate expression |
| MCF7 | 11.2 | Breast cancer; moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.94G>A (p.Gly32Arg) | Missense | <0.01% | Reported in COSMIC; potential impact on SUMO conjugation |
| c.157C>T (p.Arg53Trp) | Missense | <0.01% | ClinVar; uncertain significance |
| c.226A>G (p.Ile76Val) | Missense | <0.01% | COSMIC; no functional data |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in SUMO3.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in SUMO3.
Dominant Negative (DN)
No dominant-negative mutations reported in SUMO3.
View complete mutation data：
Gene Ontology (GO)
| • GO:0016925 - protein sumoylation | • GO:0005634 - nucleus |
| • GO:0005829 - cytosol | • GO:0005515 - protein binding |
| • GO:0042802 - identical protein binding | • GO:0031625 - ubiquitin protein ligase binding |
Pathways
• SUMOylation (Reactome: R-HSA-2990846)
• SUMO E3 ligases SUMOylate target proteins (Reactome: R-HSA-3108232)
• Regulation of TP53 Activity through SUMOylation (Reactome: R-HSA-6804757)
Protein Summary
SUMO3 is a 103-amino acid protein (11.6 kDa) that is post-translationally processed to expose a C-terminal diglycine motif required for conjugation. It is ubiquitously expressed and localizes to the nucleus and cytosol. SUMO3 shares 96% sequence identity with SUMO2 and can form poly-SUMO chains via internal lysine residues. The protein is involved in nuclear transport, transcriptional regulation, DNA repair, and stress granule assembly.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| SUMO3 Knockout HEK293 Cell Line | EDJ-KQ3140 | Human | 6612 | Details Get a Quote |
| SUMO3 Knockout A-549 Cell Line | EDJ-KQ24526 | Human | 6612 | Details Get a Quote |
| SUMO3 Knockout HCT 116 Cell Line | EDJ-KQ24527 | Human | 6612 | Details Get a Quote |
| SUMO3 Knockout HeLa Cell Line | EDJ-KQ24528 | Human | 6612 | Details Get a Quote |
| SUMO3 Knockout HAP1 Cell Line | EDC07856 | Human | 6612 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
